| Comparison of the Expiratory Isovolume Pressure Flow Relationship Generated With Stop-Flow and Esophageal Balloon Methods. | |
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MedLine Citation:
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PMID: 21352665 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Maximum expiratory flow is a useful measurement of lung mechanics because of its reproducibility, ease of measurement, and sensitivity to changes in lung mechanical properties. Expiratory isovolume pressure - flow (IVPF) curves allow determination of both flow limitation and airway resistance and effect of disease or treatment on these. However, due to the need to pass esophageal balloons (EB) using the classic techniques1 few studies now use these techniques for understanding the effects of disease or treatment on these measures. Research in the progression or regression with treatment of obstructive airways disease could potentially be facilitated if there was an easy and noninvasive technique for construction of IVPF curves. OBJECTIVE: The goal was to investigate the use of stop - flow (SF) for construction of IVPF curves instead of the invasive EB method. The difference between the pressures (Pmax) and flow (Qmax) at which flow limitation first occurred and correlation between the stop - flow and esophageal balloon methods were studied. METHODS: IVPF curves, showing the pressure at which the flow becomes limited during forced expiration, were constructed in five healthy subjects with the classical invasive method of EB and the alternative noninvasive method of SF at 25, 50, and 75 % vital capacity (VC). RESULTS: When pleural pressures were compared, on average, PSF,max was 2.7 and 1.6 times PEB,Plmax at 25 %VC and 50 %VC, respectively. QSF,max was 0.7 and 0.6 times QEB,max at 25 %VC and 50 %VC, respectively. The resistance, the inverse of the slope of the line to the point of flow limitation, with both methods was also compared. But due to very large variation in resistance values, there was no statistically significant relationship between the stop - flow and esophageal balloon methods. CONCLUSION: Stop - flow method showed potential to construct IVPF curves for everyday use. |
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Authors:
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Derya C Coursey; Steven M Scharf; Arthur T Johnson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-21 |
Journal Detail:
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Title: Respiratory care Volume: - ISSN: 0020-1324 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7510357 Medline TA: Respir Care Country: - |
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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