| Comparison of the etiology of viral respiratory illnesses in inner-city and suburban infants. | |
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MedLine Citation:
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PMID: 23014674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The risk of developing childhood asthma has been linked to the severity and etiology of viral respiratory illnesses in early childhood. Since inner-city infants have unique environmental exposures, we hypothesized that patterns of respiratory viral infections would also be distinct. METHODS: We compared the viral etiology of respiratory illnesses in 2 groups: a cohort of 515 infants from 4 inner-city areas and a cohort of 285 infants from mainly suburban Madison, Wisconsin. Nasal secretions were sampled during periods of respiratory illness and at 1 year of age and were analyzed for viral pathogens by multiplex polymerase chain reaction. RESULTS: Overall, inner-city infants had lower rates of viral detection. Considering specific viruses, sick urban infants had lower rates of detectable rhinovirus or respiratory syncytial virus infection and higher rates of adenovirus infection. Every urban site had a higher proportion of adenovirus-positive samples associated with illnesses (10%-21%), compared with Madison (6%). CONCLUSIONS: These findings provide evidence that inner-city babies have different patterns of viral respiratory illnesses than babies who grow up in a more suburban location. These findings raise important questions about the etiology of virus-negative illnesses in urban infants and the possibility of long-term consequences of early life infections with adenovirus in this population. |
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Authors:
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James E Gern; Tressa Pappas; Cynthia M Visness; Katy F Jaffee; Robert F Lemanske; Alkis Togias; Gordon R Bloomberg; William W Cruikshank; Carin Lamm; Marina Tuzova; Robert A Wood; Wai Ming Lee |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2012-09-25 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 206 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-10 Completed Date: 2013-01-04 Revised Date: 2013-05-08 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1342-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of Wisconsin, Madison, WI, USA. gern@medicine.wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cohort Studies Exudates and Transudates / virology Humans Infant Infant, Newborn Longitudinal Studies Male Multiplex Polymerase Chain Reaction Nose / virology Respiratory Tract Infections / epidemiology*, virology* Suburban Population Urban Population Virus Diseases / epidemiology*, virology* Viruses / classification, genetics, isolation & purification Wisconsin / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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1UL1RR024156/RR/NCRR NIH HHS; 1UL1RR025771/RR/NCRR NIH HHS; 5UL1RR024992-02/RR/NCRR NIH HHS; M01RR00071/RR/NCRR NIH HHS; M01RR00533/RR/NCRR NIH HHS; N01-AI-25482/AI/NIAID NIH HHS; N01-AI-25496/AI/NIAID NIH HHS; RR00052/RR/NCRR NIH HHS; UL1 TR000427/TR/NCATS NIH HHS |
| Comments/Corrections | |
Comment In:
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J Infect Dis. 2012 Nov;206(9):1331-3
[PMID:
23014673
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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