Document Detail


Comparison of the etiology of viral respiratory illnesses in inner-city and suburban infants.
MedLine Citation:
PMID:  23014674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The risk of developing childhood asthma has been linked to the severity and etiology of viral respiratory illnesses in early childhood. Since inner-city infants have unique environmental exposures, we hypothesized that patterns of respiratory viral infections would also be distinct.
METHODS: We compared the viral etiology of respiratory illnesses in 2 groups: a cohort of 515 infants from 4 inner-city areas and a cohort of 285 infants from mainly suburban Madison, Wisconsin. Nasal secretions were sampled during periods of respiratory illness and at 1 year of age and were analyzed for viral pathogens by multiplex polymerase chain reaction.
RESULTS: Overall, inner-city infants had lower rates of viral detection. Considering specific viruses, sick urban infants had lower rates of detectable rhinovirus or respiratory syncytial virus infection and higher rates of adenovirus infection. Every urban site had a higher proportion of adenovirus-positive samples associated with illnesses (10%-21%), compared with Madison (6%).
CONCLUSIONS: These findings provide evidence that inner-city babies have different patterns of viral respiratory illnesses than babies who grow up in a more suburban location. These findings raise important questions about the etiology of virus-negative illnesses in urban infants and the possibility of long-term consequences of early life infections with adenovirus in this population.
Authors:
James E Gern; Tressa Pappas; Cynthia M Visness; Katy F Jaffee; Robert F Lemanske; Alkis Togias; Gordon R Bloomberg; William W Cruikshank; Carin Lamm; Marina Tuzova; Robert A Wood; Wai Ming Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-25
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  206     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-01-04     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1342-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Exudates and Transudates / virology
Humans
Infant
Infant, Newborn
Longitudinal Studies
Male
Multiplex Polymerase Chain Reaction
Nose / virology
Respiratory Tract Infections / epidemiology*,  virology*
Suburban Population
Urban Population
Virus Diseases / epidemiology*,  virology*
Viruses / classification,  genetics,  isolation & purification
Wisconsin / epidemiology
Grant Support
ID/Acronym/Agency:
1UL1RR024156/RR/NCRR NIH HHS; 1UL1RR025771/RR/NCRR NIH HHS; 5UL1RR024992-02/RR/NCRR NIH HHS; M01RR00071/RR/NCRR NIH HHS; M01RR00533/RR/NCRR NIH HHS; N01-AI-25482/AI/NIAID NIH HHS; N01-AI-25496/AI/NIAID NIH HHS; RR00052/RR/NCRR NIH HHS; UL1 TR000427/TR/NCATS NIH HHS
Comments/Corrections
Comment In:
J Infect Dis. 2012 Nov;206(9):1331-3   [PMID:  23014673 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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