Document Detail

A comparison of endothelial cell loss after phacoemulsification in penetrating keratoplasty patients and normal patients.
MedLine Citation:
PMID:  20308877     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare phacoemulsification-related endothelial cell loss in transplanted corneas and normal corneas. METHODS: Forty-nine patients who underwent phacoemulsification/intraocular lens insertion after penetrating keratoplasty (PK-CAT group) (50 eyes) were compared with 65 patients who underwent phacoemulsification/intraocular lens insertion only (CAT group) (100 eyes). The PK-CAT group was divided into corneal endothelial dysfunction (CED) and opacity subgroups according to recipient endothelial function. Effective phacoemulsification time and endothelial density were analyzed. RESULTS: The endothelial cell density after cataract surgery from 1 month (1772.72 +/- 315.89) to 24 months (917.25 +/- 372.75) in the PK-CAT group was significantly lower than that before cataract surgery (2189.36 +/- 358.68) (P < 0.05) but that in CAT group was not significantly different from baseline during follow-up time (P < 0.05). The rate of graft survival in the opacity subgroup (82.0%) of the PK-CAT group was higher than that in the CED subgroup (54.5%) after 2 years (P < 0.05). The mean endothelial density in the opacity subgroup (1216.73 +/- 271.63 cells/mm2) of the PK-CAT group was significantly higher than that in the CED subgroup (632.50 +/- 238.29 cells/mm2) at 2 years after cataract surgery (P < 0.05). CONCLUSIONS: The phacoemulsification-related endothelial cell loss in transplanted corneas was higher than that in normal corneas. A possible factor contributing to higher endothelial cell loss in transplanted corneas is recipient endothelial dysfunction.
Eun Chul Kim; Man Soo Kim
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cornea     Volume:  29     ISSN:  1536-4798     ISO Abbreviation:  Cornea     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  510-5     Citation Subset:  IM    
Department of Ophthalmology and Visual Science, College of Medicine, Catholic University of Korea, Seoul, Korea.
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MeSH Terms
Case-Control Studies
Cell Count
Corneal Endothelial Cell Loss / diagnosis,  etiology*
Endothelium, Corneal / pathology
Follow-Up Studies
Graft Survival
Keratoplasty, Penetrating*
Lens Implantation, Intraocular
Middle Aged
Phacoemulsification / adverse effects*
Retrospective Studies
Risk Factors
Visual Acuity / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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