| Comparison of the effects on lipid metabolism of dietary methionine and cystine between hepatoma-bearing and normal rats. | |
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MedLine Citation:
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PMID: 20057121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of dietary supplementation with methionine and cystine on lipid metabolism, including the serum lipid concentration, were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line (AH109A) for comparison with normal rats. A diet supplemented with 1.2% L-methionine or L-cystine to 20% casein was found to suppress the hepatoma-induced increases in serum triglyceride and total cholesterol concentration. The lipoprotein lipase activity in tissues was enhanced by dietary methionine and cystine, with no change in the mRNA level. Dietary methionine and cystine increased bile acid excretion into the feces with enhanced hepatic cholesterol 7alpha-hydroxylase activity. Dietary methionine and cystine affected the lipid metabolism differently in normal rats from hepatoma-bearing rats. These results suggest that dietary methionine and cystine each had a hypolipidemic effect against cancer-induced hyperlipidemia, and that the different actions observed in the hepatoma-bearing and normal rats may have been due to a metabolic abnormality caused by the cancer. |
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Authors:
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Masashi Kawasaki; Yutaka Miura; Ryuhei Funabiki; Kazumi Yagasaki |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-01-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 74 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-04-05 Revised Date: 2010-05-26 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 158-67 Citation Subset: IM |
Affiliation:
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Department of Applied Biological Science, Tokyo Noko University, Fuchu, Tokyo, Japan. masashi@iwate-pu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology* Body Weight / drug effects Carcinoma, Hepatocellular / blood, metabolism*, physiopathology Cystine / pharmacology* Diet* Eating / drug effects Lipid Metabolism / drug effects* Lipids / blood Lipolysis / drug effects Liver Neoplasms / blood, metabolism*, physiopathology Male Methionine / pharmacology* Rats |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Lipids; 56-89-3/Cystine; 63-68-3/Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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