| Comparison of early and late changes in immunoglobulins and acute phase reactants after laparoscopic adjustable gastric banding in patients with morbid obesity. | |
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MedLine Citation:
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PMID: 20066501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There are differences in the levels of inflammation mediators, lipids, and formed elements of the blood in morbidly obese patients compared with individuals of normal weight. In the current study, the change in these parameters was determined in patients who achieved weight loss by undergoing laparoscopic adjustable gastric banding (LAGB) by comparing preoperative, and early (3 months) and late (12 months) postoperative values. METHODS: The body mass index (BMI), weight, blood pressure, and waist circumference of 72 patients treated by LAGB procedures between September 2006 and February 2009 were measured and recorded. Pre- and postoperative 3- and 12-month C-reactive protein (CRP), immunoglobulin (Ig) G, IgA, IgM, fibrinogen (Fbg), complement components C3 and C4, total cholesterol, triglycerides, low-density lipoprotein-C and high-density lipoprotein-C levels, and leukocyte, neutrophil, lymphocyte, and platelet counts were also measured. Results were presented as mean +/- SD. The preoperative values were compared with the 3- and 12-month values. A p value < 0.05 was considered statistically significant. RESULTS: BMI, weight, blood pressure, and waist circumference measurements were reduced at 3 and 12 months postoperatively compared with preoperative values (p < 0.05). Among the inflammatory mediators, IgG, IgM, and Fbg were reduced to near-normal values, beginning in the early postoperative period (p < 0.05). There was no significant reduction parallel to weight loss with respect to CRP, C3, C4, and IgA values at 3 months postoperatively (p > 0.05). However, the 12-month values of these parameters were significantly reduced (p < 0.05). CONCLUSIONS: Morbid obesity leads to significant changes in the levels of inflammation mediators. While there is a significant reduction in some of these mediators accompanying slight weight loss in the early period following an LAGB procedure, significant changes occur in other mediators in the late period when there is a larger amount of weight loss. |
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Authors:
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Ibrahim Sakçak; Mehmet Fatih Avşar; Enver Okan Hamamci; Settar Bostanoğlu; Muhittin Sonişik; Akin Bostanoğlu; Nihal Zekiye Erdem; Erdal Coşgun |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-01-12 |
Journal Detail:
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Title: Obesity surgery Volume: 20 ISSN: 1708-0428 ISO Abbreviation: Obes Surg Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106714 Medline TA: Obes Surg Country: United States |
Other Details:
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Languages: eng Pagination: 610-5 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Numune Teaching and Research Hospital, 06100 Ankara, Turkey. ibrahimsakcak@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure C-Reactive Protein / analysis Cholesterol, HDL / blood Cholesterol, LDL / blood Complement C3 / analysis Complement C4 / analysis Female Gastroplasty / methods* Humans Immunoglobulins / blood* Laparoscopy / methods Leukocyte Count Male Obesity, Morbid / blood*, surgery* Time Factors Treatment Outcome Triglycerides / blood Weight Loss* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Complement C3; 0/Complement C4; 0/Immunoglobulins; 0/Triglycerides; 9007-41-4/C-Reactive Protein |
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