| Comparison of Dynamic Expiratory CT With Bronchoscopy for Diagnosing Airway Malacia: A Pilot Evaluation. | |
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MedLine Citation:
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PMID: 17356090 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the accuracy of dynamic expiratory CT for detecting airway malacia using bronchoscopy as the diagnostic "gold standard." MATERIALS AND METHODS: A computerized hospital information system was used to retrospectively identify all patients with bronchoscopically proven airway malacia referred for CT airway imaging at our institution during a 19-month period. CT was performed within 1 week of bronchoscopy. All patients were scanned with a standard protocol, including end-inspiratory and dynamic expiratory volumetric imaging, using an eight-detector multislice helical CT scanner. For both CT and bronchoscopy, malacia was defined as >/= 50% expiratory reduction of the airway lumen. CT and bronchoscopic findings were subsequently jointly reviewed by the radiologist and bronchoscopist for concordance. RESULTS: Twenty-nine patients (12 men and 17 women; mean age, 60 years; range, 36 to 79 years) comprised the study cohort. CT correctly diagnosed malacia in 28 of 29 patients (97%). The most common presenting symptoms were dyspnea in 20 patients (69%), severe or persistent cough in 16 patients (55%), and recurrent infection in 7 patients (24%). The estimated radiation dose (expressed as dose-length product) for the dual-phase study is 508 mGy-cm, which is comparable to a routine chest CT. CONCLUSION: Dynamic expiratory CT is a highly sensitive method for detecting airway malacia and has the potential to serve as an effective, noninvasive test for diagnosing this condition. |
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Authors:
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Karen S Lee; Maryellen R M Sun; Armin Ernst; David Feller-Kopman; Adnan Majid; Phillip M Boiselle |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 131 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-14 Completed Date: 2007-05-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 758-64 Citation Subset: AIM; IM |
Affiliation:
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Division of Thoracic Surgery and Interventional Pulmonary, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215. aernst@bidmc.harvard.edu. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bronchial Diseases / diagnosis* Bronchoscopy* Cartilage Diseases / diagnosis* Cohort Studies Exhalation / physiology* Female Humans Image Processing, Computer-Assisted* Male Middle Aged Radiation Dosage Sensitivity and Specificity Statistics as Topic Tomography, Spiral Computed* Tracheal Diseases / diagnosis* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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