Document Detail


Comparison of Doppler ultrasonography and the hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis.
MedLine Citation:
PMID:  12653891     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM: This prospective study aimed to determine whether Doppler ultrasonography can represent the hepatic venous pressure gradient (HVPG) as an assessment of the severity of portal hypertension and the response to terlipressin, which reduces the portal pressure in liver cirrhosis. METHODS: The HVPG and the Doppler ultrasonographic parameters, such as the portal venous velocity and the splenic venous velocity, the pulsatility and the resistive index of the hepatic, splenic and renal arteries were measured in 138 patients with liver cirrhosis. The changes in the HVPG and the portal venous velocity after administering terlipressin were evaluated in 43 of the 138 patients. The patients who showed a reduction in the HVPG of more than 20% of the baseline were defined as responders to terlipressin. RESULTS: None of the Doppler ultrasonographic parameters correlated with the HVPG. Both the HVPG (28.0 +/- 19.8%) and the portal venous velocity (29.7 +/- 13.2%) showed a significant reduction after terlipressin administration. However, the portal venous velocity decreased significantly, not only in the responders (31.0 +/- 12.0%) but also in the non-responders (25.2 +/- 16.4%). CONCLUSIONS: Doppler ultrasonography does not represent the HVPG, and is therefore not suitable for replacing HVPG as a means of assessing the severity of portal hypertension and the response to drugs which reduce the portal pressure in liver cirrhosis.
Authors:
Yeun Jong Choi; Soon Koo Baik; Dong Hoon Park; Moon Young Kim; Hyun Soo Kim; Dong Ki Lee; Sang Ok Kwon; Young Ju Kim; Joong Wha Park
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  18     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-25     Completed Date:  2003-08-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  424-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Blackwell Publishing Asia Pty Ltd
Affiliation:
Departments of Internal Medicine, Wonju College of Medicine, Wonju, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antihypertensive Agents / therapeutic use
Blood Flow Velocity / drug effects,  physiology
Blood Pressure / drug effects,  physiology*
Female
Hepatic Veins / drug effects,  physiopathology*,  ultrasonography*
Humans
Hypertension, Portal / drug therapy,  physiopathology*,  ultrasonography*
Liver Cirrhosis / drug therapy,  physiopathology*,  ultrasonography*
Lypressin / analogs & derivatives*,  therapeutic use
Male
Middle Aged
Prospective Studies
Pulsatile Flow / drug effects,  physiology
Reproducibility of Results
Severity of Illness Index
Ultrasonography, Doppler*
Vascular Resistance / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 14636-12-5/terlipressin; 50-57-7/Lypressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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