Document Detail


Comparison of Diskus inhaler, a new multidose powder inhaler, with Diskhaler inhaler for the delivery of salmeterol to asthmatic patients. Canadian Study Group.
MedLine Citation:
PMID:  7592246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Administration of the long-acting beta 2-adrenoceptor agonist salmeterol from a new, easy-to-operate, multidose powder inhaler (Diskus) containing 60 sealed doses in a foil strip has been compared with administration from a Diskhaler inhaler in a multicenter, double-blind, double-dummy, parallel-group study. Asthmatic patients taking anti-inflammatory treatment, with baseline FEV1 > or = 60% and < or = 90% predicted were treated for 4 weeks with salmeterol 50 micrograms twice daily from either the Diskus or Diskhaler inhaler. The two treatments were equivalent (90% CLs for the difference in mean morning PEFR: -2.2, 8.7 L/min). The Diskus inhaler was rated easier to use and was preferred by more patients than the Diskhaler inhaler (73% vs. 15%).
Authors:
L P Boulet; R Cowie; P Johnston; D Krakovsky; S Mark
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  32     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  1995  
Date Detail:
Created Date:  1995-12-22     Completed Date:  1995-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-36     Citation Subset:  IM    
Affiliation:
Hôpital Laval, Sainte-Foy, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenergic beta-Agonists / administration & dosage*,  therapeutic use
Adult
Aged
Albuterol / administration & dosage,  analogs & derivatives*,  therapeutic use
Asthma / drug therapy*,  physiopathology
Child
Double-Blind Method
Equipment Design
Female
Humans
Male
Middle Aged
Nebulizers and Vaporizers*
Patient Satisfaction
Peak Expiratory Flow Rate
Powders
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Powders; 18559-94-9/Albuterol; 89365-50-4/salmeterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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