Document Detail


Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma.
MedLine Citation:
PMID:  23532529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage.
METHODS: The study included 142 eyes from 91 patients suspected of having the disease based on the appearance of the optic disc. All eyes had normal visual fields before the imaging session. Forty-eight eyes with progressive glaucomatous damage were included in the preperimetric glaucoma group. Ninety-four eyes without any evidence of progressive glaucomatous damage and followed untreated for 12.8 ± 3.6 years were used as controls. Areas under the receiver operating characteristic curves (AUC) were calculated to summarize diagnostic accuracies of the parameters.
RESULTS: The three RNFL parameters with the largest AUCs were average RNFL thickness (0.89 ± 0.03), inferior hemisphere average thickness (0.87 ± 0.03), and inferior quadrant average thickness (0.85 ± 0.03). The three ONH parameters with the largest AUCs were vertical cup-to-disc ratio (0.74 ± 0.04), rim area (0.72 ± 0.05), and rim volume (0.72 ± 0.05). The three macular parameters with the largest AUCs were GCC average thickness (0.79 ± 0.04), GCC inferior thickness (0.79 ± 0.05), and GCC superior thickness (0.76 ± 0.05). Average RNFL thickness performed better than vertical cup-to-disc ratio (0.89 vs. 0.74; P = 0.007) and GCC average thickness (0.89 vs. 0.79; P = 0.015).
CONCLUSIONS: SDOCT RNFL measurements performed better than ONH and macular measurements for detecting preperimetric glaucomatous damage in a cohort of glaucoma suspects. (ClinicalTrials.gov number, NCT00221897.).
Authors:
Renato Lisboa; Augusto Paranhos; Robert N Weinreb; Linda M Zangwill; Mauro T Leite; Felipe A Medeiros
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2013-05-13
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  54     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-14     Completed Date:  2013-07-15     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3417-25     Citation Subset:  IM    
Affiliation:
Hamilton Glaucoma Center, Department of Ophthalmology, University of California-San Diego, La Jolla, CA, USA.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00221897
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MeSH Terms
Descriptor/Qualifier:
Aged
Area Under Curve
Female
Follow-Up Studies
Humans
Intraocular Pressure / physiology
Male
Middle Aged
Nerve Fibers / pathology*
Ocular Hypertension / diagnosis*,  physiopathology
Optic Disk / pathology*
Optic Nerve Diseases / diagnosis*,  physiopathology
Reproducibility of Results
Retinal Ganglion Cells / pathology*
Tomography, Optical Coherence / methods*
Tonometry, Ocular
Visual Acuity / physiology
Visual Field Tests
Visual Fields / physiology
Grant Support
ID/Acronym/Agency:
R01 EY021818/EY/NEI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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