Document Detail


Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines.
MedLine Citation:
PMID:  24312815     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Farnesyltransferase (FTase) is a zinc-dependent enzyme that adds a farnesyl group to the Ras proteins. L778, 123 is a potent peptidomimetic imidazole-containing FTase inhibitor.
METHODS: L778123 was synthesized according to known methods and evaluated alone and in combination with doxorubicin against A549 (adenocarcinomic human alveolar basal epithelial cells) and HT29 (human colonic adenocarcinoma) cell lines by MTT assay.
RESULTS: L778123 showed weak cytotoxic activity with IC50 of 100 and 125 for A549 and HT-29 cell lines, respectively. The combination of doxorubicin and L778123 can decrease IC50 of doxorubicin in both cell lines significantly.
CONCLUSION: It can be concluded that L778, 123 can be a good agent for combination therapy.
Authors:
Saeed Ghasemi; Soodabeh Davaran; Simin Sharifi; Davoud Asgari; Ali Abdollahi; Javid Shahbazi Mojarrad
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Publication Detail:
Type:  Journal Article     Date:  2013-02-07
Journal Detail:
Title:  Advanced pharmaceutical bulletin     Volume:  3     ISSN:  2228-5881     ISO Abbreviation:  Adv Pharm Bull     Publication Date:  2013  
Date Detail:
Created Date:  2013-12-06     Completed Date:  2013-12-06     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101578021     Medline TA:  Adv Pharm Bull     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  -    
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