Document Detail

Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines.
MedLine Citation:
PMID:  24312815     Owner:  NLM     Status:  PubMed-not-MEDLINE    
PURPOSE: Farnesyltransferase (FTase) is a zinc-dependent enzyme that adds a farnesyl group to the Ras proteins. L778, 123 is a potent peptidomimetic imidazole-containing FTase inhibitor.
METHODS: L778123 was synthesized according to known methods and evaluated alone and in combination with doxorubicin against A549 (adenocarcinomic human alveolar basal epithelial cells) and HT29 (human colonic adenocarcinoma) cell lines by MTT assay.
RESULTS: L778123 showed weak cytotoxic activity with IC50 of 100 and 125 for A549 and HT-29 cell lines, respectively. The combination of doxorubicin and L778123 can decrease IC50 of doxorubicin in both cell lines significantly.
CONCLUSION: It can be concluded that L778, 123 can be a good agent for combination therapy.
Saeed Ghasemi; Soodabeh Davaran; Simin Sharifi; Davoud Asgari; Ali Abdollahi; Javid Shahbazi Mojarrad
Related Documents :
7029715 - Autoimmune encephalomyelitis: simultaneous identification of t and b cells in the targe...
23549675 - Protein normalization in different adipocyte models and dependence on cell size.
24736075 - Glucocorticoid receptor status is a principal determinant of variability in the sensiti...
24856835 - Modeling the role of igf-1 on extracellular matrix biosynthesis and cellularity in inte...
19799515 - Estradiol-17beta treatment induces intersexual gonadal development in the pufferfish, t...
7271315 - Influence of intercellular agents on proliferation and gene activity of cultured human ...
Publication Detail:
Type:  Journal Article     Date:  2013-02-07
Journal Detail:
Title:  Advanced pharmaceutical bulletin     Volume:  3     ISSN:  2228-5881     ISO Abbreviation:  Adv Pharm Bull     Publication Date:  2013  
Date Detail:
Created Date:  2013-12-06     Completed Date:  2013-12-06     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101578021     Medline TA:  Adv Pharm Bull     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Design and characterization of microemulsion systems for naproxen.
Next Document:  Multivariate chemometric assisted analysis of metformin hydrochloride, gliclazide and pioglitazone h...