Document Detail

Comparison of continuous thoracic epidural with paravertebral block on perioperative analgesia and hemodynamic stability in patients having open lung surgery.
MedLine Citation:
PMID:  21490523     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Epidural analgesia can result in perioperative hypotension in patients having thoracotomy. This randomized prospective study assessed the effects of epidural and paravertebral analgesia on hemodynamics during thoracotomy.
METHODS: Thirty-two patients were randomized to receive either epidural analgesia (n = 16, 0.25% levobupivacaine and 30 μg/kg morphine) or paravertebral block (n = 16; 0.5% levobupivacaine and 30 μg/kg morphine). Oxygen delivery, stroke volume and systemic vascular resistance indices, heart rate, and mean arterial pressure measurements were performed before administration of local anesthetic, after induction of general anesthesia, institution of 1-lung ventilation, first skin incision, retractor placement, lung-inflation maneuver, and at last skin suture. The primary end point was the volume of the colloid infusion necessary to maintain oxygen delivery index of 500 mL/min per squared meter or higher. Postoperative analgesia was provided immediately after surgery by an infusion of 0.125% levobupivacaine and 20 μg/mL morphine in epidural/paravertebral infusion. Pain, rescue-analgesia consumption, arterial pressure, and heart rate were recorded at 6, 24, and 48 hrs after surgery. Administration of anesthesia and data collection were done by research staff blinded to the regional analgesia technique.
RESULTS: The groups did not differ significantly in heart rate, mean arterial blood pressure, or systemic vascular resistance indices. However, to maintain the targeted oxygen delivery index, a greater volume of colloid infusion and phenylephrine were required, respectively, in the epidural than in the paravertebral group (554 ± 50 vs 196 ± 75 mL, P = 0.04; and 40 ± 10 vs 17 ± 4 μg, P = 0.04). Pain intensity before and after respiratory physiotherapy as well as 24 hr rescue piritramide consumption was similar in the epidural (4.1 ± 3.1 mg) and the paravertebral (2.5 ± 1.5 mg) groups (P = 0.14). Systolic blood pressure after 24 and 48 hrs was lower in the epidural group.
CONCLUSIONS: Under the conditions of our study, continuous paravertebral block resulted in similar analgesia but greater hemodynamic stability than epidural analgesia in patients having thoracotomy. Paravertebral block also required smaller volume of colloids and vasopressors to maintain the target oxygen delivery index (DO2I).
Tatjana Stopar Pintaric; Iztok Potocnik; Admir Hadzic; Tomaz Stupnik; Miha Pintaric; Vesna Novak Jankovic
Related Documents :
1890883 - Tail-cuff detection of systolic hypertension in different strains of ageing rats.
15699473 - Central neuropeptide y signaling ameliorates n(omega)-nitro-l-arginine methyl ester hyp...
1695313 - Long-term lipid profiles with isradipine and hydrochlorothiazide treatment in elderly h...
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Regional anesthesia and pain medicine     Volume:  36     ISSN:  1532-8651     ISO Abbreviation:  Reg Anesth Pain Med     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-04-21     Completed Date:  2012-03-07     Revised Date:  2013-11-04    
Medline Journal Info:
Nlm Unique ID:  9804508     Medline TA:  Reg Anesth Pain Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
Department of Anesthesiology and Intensive Therapy, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analgesia, Epidural* / methods
Double-Blind Method
Hemodynamics / drug effects,  physiology*
Lung / pathology,  surgery*
Middle Aged
Nerve Block* / methods
Pain, Postoperative / etiology,  physiopathology,  prevention & control*
Perioperative Care / methods
Prospective Studies
Thoracic Vertebrae
Thoracotomy* / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  S-Ketamine Modulates Hyperalgesia in Patients With Chronic Pancreatitis Pain.
Next Document:  Vernal keratoconjunctivitis with limbal stem cell deficiency.