| Comparison of Aliskiren/Hydrochlorothiazide Combination Therapy With Hydrochlorothiazide Monotherapy in Older Patients With Stage 2 Systolic Hypertension: Results of the ACTION Study. | |
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MedLine Citation:
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PMID: 21366847 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Patients with stage 2 systolic hypertension require sizable blood pressure (BP) reductions to achieve recommended targets. This randomized double-blind study compared a single-pill combination of the direct renin inhibitor aliskiren and hydrochlorothiazide (aliskiren/HCTZ) with HCTZ monotherapy in older patients (older than 55 years) with systolic BP ≥160 mm Hg and <200 mm Hg. After a 1- to 4-week washout, 451 patients were randomized to once-daily aliskiren/HCTZ 150/12.5 mg or HCTZ 12.5 mg for 1 week, and then double the doses for 7 weeks. Overall baseline BP was 168.8/91.4 mm Hg. At week 4 (primary) end point, aliskiren/HCTZ provided significantly greater BP reductions from baseline than HCTZ monotherapy (29.6/9.3 mm Hg vs 22.3/6.8 mm Hg) and resulted in a greater proportion of patients achieving BP goal of <140/90 mm Hg (51.1% vs 33.3%). Aliskiren/HCTZ therapy provides substantial BP reductions and may thus be a useful treatment option for older patients with stage 2 hypertension. J Clin Hypertens (Greenwich). 2011;13:162-169. © 2011 Wiley Periodicals, Inc. |
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Authors:
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Jan Basile; Simon Babazadeh; Michael Lillestol; Jaco Botha; Carol Yurkovic; Richard Weitzman |
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Publication Detail:
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Type: Journal Article Date: 2011-01-25 |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 13 ISSN: 1751-7176 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 162-9 Citation Subset: IM |
Copyright Information:
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© 2011 Wiley Periodicals, Inc. |
Affiliation:
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From the Ralph H Johnson VA Medical Center and Medical University of South Carolina, Charleston, SC;Crest Clinical Trials Inc, Santa Ana, CA;Lillestol Research LLC, Fargo, ND;Novartis Pharma AG, Basel, Switzerland;Novartis Pharmaceuticals Corporation, East Hanover, NJ. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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