| Comparison of Coapsys annuloplasty and internal reduction mitral annuloplasty in the randomized treatment of functional ischemic mitral regurgitation: impact on the left ventricle. | |
| | |
MedLine Citation:
|
PMID: 16678595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Functional mitral regurgitation is associated with both annular and ventricular distortion. Aggressive reduction annuloplasty for functional mitral regurgitation acts primarily at the annulus, with variable impact on the left ventricle. The Coapsys device externally reshapes the left ventricle to correct functional mitral regurgitation. Left ventricular reshaping was analyzed in a randomized study. METHODS: The RESTOR-MV study randomizes patients with coronary artery disease and functional mitral regurgitation to either reduction annuloplasty and coronary artery bypass grafting (the RA group) or Coapsys annuloplasty and bypass grafting (the CO group). The Coapsys device consists of epicardial pads connected by a cord. It was placed without cardiopulmonary bypass under echocardiographic guidance and sized to reduce annular dimension and improve leaflet coaptation. Internal reduction annuloplasty was performed by device placement. Intraoperative transesophageal echocardiograms were analyzed in 7 patients having reduction annuloplasty and 7 having Coapsys annuloplasty. RESULTS: Baseline mitral regurgitation (0-4 scale) was similar for the RA (3.0 +/- 0.6) and the CO groups (3.0 +/- 0.6). Intraoperative mitral regurgitation was reduced from 2.86 +/- 0.7 to 0.5 +/- 0.7 (P < .01 pre vs post) for the RA group and from 2.64 +/- 0.9 to 05 +/- 0.7 (P < .01 pre vs post) for the CO group. Annular anteroposterior diameter was reduced with both techniques: RA, 3.45 +/- 0.39 to 2.34 +/- 0.37 cm (P < .01 pre vs post); CO, 3.40 +/- 0.27 to 2.85 +/- 0.34 cm (P < .05 pre vs post). Long-axis dimensions were unchanged with both techniques. Short-axis dimensions measured at three levels were significantly reduced only in the CO patients: basal diameter 4.77 +/- 0.58 to 3.58 +/- 0.38 cm (P < .01 pre vs post); mid diameter 4.88 +/- 0.55 to 3.57 +/- 0.43 cm (P < .01 pre vs post); and apical diameter 4.39 +/- 0.46 to 3.38 +/- 0.34 cm (P < .01 pre vs post). CONCLUSIONS: Coapsys and reduction annuloplasty techniques both acutely reduce functional mitral regurgitation and annular dimension. The Coapsys device provided significantly greater left ventricular reshaping than did reduction annuloplasty. Further evaluation will assess the long-term valvular function and ventricular geometric stability associated with both techniques. |
| | |
Authors:
|
E A Grossi; Y J Woo; C F Schwartz; D M Gangahar; V A Subramanian; N Patel; J Wudel; P L DiGiorgi; A Singh; R D Davis |
Related Documents
:
|
3678245 - Value of qualitative angiographic grading in aortic regurgitation. 7607765 - Cardiac disease after chest irradiation for hodgkin's disease: incidence in 108 patient... 2662745 - Prevalence of multivalvular regurgitation in athletes. 1927945 - Evaluation of transient mitral regurgitation in coronary artery disease. 12358415 - Double valve replacement in a patient with osteogenesis imperfecta. 18359325 - Noninvasive imaging of cardiac venous anatomy with 64-slice multi-slice computed tomogr... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2006-04-17 |
Journal Detail:
|
Title: The Journal of thoracic and cardiovascular surgery Volume: 131 ISSN: 1097-685X ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-05-08 Completed Date: 2006-05-23 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 1095-8 Citation Subset: AIM; IM |
Affiliation:
|
New York University School of Medicine and Veterans Administration NY Harbor Healthcare System, New York, NY, USA. grossi@cv.med.nyu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cardiac Surgical Procedures / instrumentation* Coronary Artery Disease / complications, surgery Female Humans Male Middle Aged Mitral Valve / surgery Mitral Valve Insufficiency / complications, surgery* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thoracic aortic stent grafting: improving results with newer generation investigational devices.
Next Document: Inclusion of oxygen consumption improves the accuracy of arterial and venous oxygen saturation inter...