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Comparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America.
MedLine Citation:
PMID:  23149388     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To compare the clinical, demographic, and serologic characteristics and the treatment of patients diagnosed with ankylosing spondylitis (AS) from Europe (EU) and Latin America (LA). METHODS: We included 3439 patients from national registries: the Spanish Registry of Spondyloarthritis (REGISPONSER), the Belgian registry (ASPECT), and the Latin American Registry of Spondyloarthropathies (RESPONDIA). We selected patients with diagnosis of AS who met the modified New York classification criteria. Demographic, clinical, disease activity, functional, and metrological measurement data were recorded. Current treatment was recorded. The population was classified into 2 groups: patients with disease duration < 10 years and those with disease duration ≥ 10 years. A descriptive and comparative analysis of variables of both groups was carried out. RESULTS: There were 2356 patients in EU group and 1083 in LA group. Prevalence of HLA-B27 was 71% in LA group and 83% in EU group (p < 0.001). We found a greater frequency of peripheral arthritis and enthesitis (p < 0.001) in the LA population; prevalence of arthritis was 57% in LA and 42% in EU, and for enthesitis, 54% and 38%. Except for treatment with anti-tumor necrosis factor (anti-TNF), the use of nonsteroidal antiinflammatory drugs (NSAID), corticosteroids, and disease-modifying antirheumatic drugs (DMARD), and the association of anti-TNF and methotrexate use showed a significant difference (p < 0.001) in the 2 populations. CONCLUSION: The principal differences in the clinical manifestations of patients with AS from EU and LA were the greater frequency of peripheral arthritis and enthesitis in LA group, the higher percentage of HLA-B27 in EU group, and the form of treatment, with a greater use of NSAID, steroids, and DMARD in the LA group.
Mariana Benegas; Elisa Muñoz-Gomariz; Pilar Font; Ruben Burgos-Vargas; José Chaves; Daniel Palleiro; José Maldonado Cocco; Miguel Gutiérrez; Ricardo Sáenz; Ivan Steckmen; Oscar Rillo; Juan Mulero; Percival Sampaio-Barros; Anabela Barcelos; Bert Vander Cruyssen; Janitzia Vazquez-Mellado; Eduardo Collantes Estevez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  The Journal of rheumatology     Volume:  -     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Rheumatology Section, Dr. E. Tornú Hospital, Buenos Aires, Argentina; Rheumatology, Reina Sofia Hospital and Universit/IMIBIC, Córdoba, Spain; Rheumatology, General Hospital of México, México City, Mexico; Rheumatology Hospital, Nacional Edgardo Rebagliati Martins, ESSALUD, Lima, Perú; Rheumatology Section, Instituto Nacional de Reumatología, Montevideo, Uruguay; Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina; Rheumatology, Pontificia Universidad Católica de Chile, Santiago, Chile; Department of Medicine, Division of Rheumatology, Hospital Dr. R.A. Calderón Guardia, San José, Costa Rica; Rheumatology Section, Hospital Universitario de Caracas, Caracas, Venezuela; Rheumatology, H. Puerta de Hierro, Madrid, Spain; División de Reumatología, Faculdad de Medicina, Universidad de São Paulo, São Paulo, Brasil; Rheumatology, Hospital Infante D. Pedro, Aveiro, Portugal; and Department of Rheumatology, Ghent University Hospital, Gent, Belgium.
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