Document Detail

A comparison of central and mixed venous oxygen saturation in circulatory failure.
MedLine Citation:
PMID:  18834813     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate whether central venous oxygen saturation can be used as an alternative to mixed venous oxygen saturation in patients with cardiogenic and septic shock. DESIGN: Prospective clinical study. SETTING: A tertiary intensive care unit in a university hospital. PARTICIPANTS: Twenty patients with cardiogenic or septic shock requiring a pulmonary artery catheter and inotropic support. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The central venous oxygen saturation overestimated the mixed venous oxygen saturation by a mean bias (or an absolute difference) of 6.9%, and the 95% limits of agreement were large (-5.0% to 18.8%). The difference between central and mixed venous oxygen saturation appeared to be more significant when mixed venous oxygen saturation was <70%. The changes in central and mixed venous oxygen saturation did not follow the line of perfect agreement closely in different clinical conditions. The central or mixed venous oxygen saturation had a significant ability to predict the status of cardiac output state, but this ability was reduced when the effect of hyperoxia was not considered. CONCLUSION: Central and mixed venous oxygen saturation measurements are not interchangeable numerically.
Kwok M Ho; Richard Harding; Jenny Chamberlain; Max Bulsara
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-01-22
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  24     ISSN:  1532-8422     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Intensive Care, Royal Perth Hospital, Perth, WA, Australia.
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MeSH Terms
Cardiac Output / physiology
Cardiotonic Agents / therapeutic use
Catheterization, Swan-Ganz
Dobutamine / therapeutic use
Heart Failure / blood*
Heart Function Tests
Intra-Aortic Balloon Pumping
Middle Aged
Norepinephrine / therapeutic use
Oxygen / blood*
ROC Curve
Respiration, Artificial
Sample Size
Shock, Cardiogenic / blood
Shock, Septic / blood
Vasoconstrictor Agents / therapeutic use
Reg. No./Substance:
0/Cardiotonic Agents; 0/Vasoconstrictor Agents; 34368-04-2/Dobutamine; 51-41-2/Norepinephrine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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