| Comparison of Carotid Plaque Ulcer Detection Using Contrast-Enhanced and Time-of-Flight MRA Techniques. | |
| | |
MedLine Citation:
|
PMID: 22627797 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE:Ulceration in carotid plaque is a risk indicator for ischemic stroke. Our aim was to compare plaque ulcer detection by standard TOF and CE-MRA techniques and to identify factors that influence its detection.MATERIALS AND METHODS:Carotid MR imaging scans were acquired on 2066 participants in the ARIC study. We studied the 600 thickest plaques. TOF-MRA, CE-MRA, and black-blood MR images were analyzed together to define ulcer presence (plaque surface niche ≥2 mm in depth). Sixty ulcerated arteries were detected. These arteries were randomly assigned, along with 40 nonulcerated plaques from the remaining 540, for evaluation of ulcer presence by 2 neuroradiologists. Associations between ulcer detection and ulcer characteristics, including orientation, location, and size, were determined and explored by CFD modeling.RESULTS:One CE-MRA and 3 TOF-MRAs were noninterpretable and excluded. Of 71 ulcers in 56 arteries, readers detected an average of 39 (55%) on both TOF-MRA and CE-MRA, 26.5 (37.5%) only on CE-MRA, and 1 (1.5%) only on TOF-MRA, missing 4.5 (6%) ulcers by both methods. Ulcer detection by TOF-MRA was associated with its orientation (distally pointing versus perpendicular: OR = 5.57 [95% CI, 1.08-28.65]; proximally pointing versus perpendicular: OR = 0.21 [95% CI, 0.14-0.29]); location relative to point of maximum stenosis (distal versus isolevel: OR = 5.17 [95% CI, 2.10-12.70]); and neck-to-depth ratio (OR = 1.96 [95% CI, 1.11-3.45]) after controlling for stenosis and ulcer volume.CONCLUSIONS:CE-MRA detects more ulcers than TOF-MRA in carotid plaques. Missed ulcers on TOF-MRA are influenced by ulcer orientation, location relative to point of maximum stenosis, and neck-to-depth ratio. |
| | |
Authors:
|
M Etesami; Y Hoi; D A Steinman; S K Gujar; A E Nidecker; B C Astor; A Portanova; Y Qiao; W M A Abdalla; B A Wasserman |
Related Documents
:
|
22701137 - Fatal delayed coronary artery perforation after coronary stent implantation. 18671677 - Pulmonary hypertension associated with lung transplantation obliterative bronchiolitis ... 22865057 - Single stage transcranial exposure of large dural venous sinuses for surgically-assiste... 6771847 - Distribution of ventilation-perfusion ratios in pneumonectomized dogs. 21420777 - Endoscipic treatment of persistent alveolar-pleural air leaks with a unidirectional end... 8215197 - Study of circle of willis in 1021 consecutive autopsies: incidence of aneurysms, anatom... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-5-24 |
Journal Detail:
|
Title: AJNR. American journal of neuroradiology Volume: - ISSN: 1936-959X ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-5-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, Maryland; Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, Ontario, Canada; Department of Radiology, University of California Davis Medical Center, Sacramento, California; Departments of Medicine and Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; School of Medicine, University of Rochester Medical Center, Rochester, New York. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Use of Adaptive Statistical Iterative Reconstruction in Pediatric Head CT: A Feasibility Study.
Next Document: Diagnostic Yield of Fluoroscopy-Guided Biopsy for Infectious Spondylitis.