| Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high-cholesterol/high-fat diet in rats. | |
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MedLine Citation:
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PMID: 20482284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to investigate the comparative in vivo cardiovascular protective effects of red, green, and brown tropical seaweeds, namely, Kappaphycus alvarezii (or Eucheuma cottonii), Caulerpa lentillifera, and Sargassum polycystum, in rats fed on high-cholesterol/high-fat (HCF) diets. Male Sprague-Dawley rats (weighing 260-300 g) on the HCF diet had significantly increased body weight, plasma total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDL-C), plasma triglycerides (TG), lipid peroxidation, and erythrocyte glutathione peroxidase (GSH-Px) and superoxide dismutase levels after 16 weeks. Supplementing 5% seaweeds to HCF diet significantly reduced plasma TC (-11.4% to -18.5%), LDL-C (-22% to -49.3%), and TG (-33.7% to -36.1%) levels and significantly increased HDL-C levels (16.3-55%). Among the seaweeds, S. polycystum showed the best anti-obesity and blood GSH-Px properties, K. alvarezii showed the best antihyperlipemic and in vivo antioxidation effects, and C. lentillifera was most effective at reducing plasma TC. All seaweeds significantly reduced body weight gain, erythrocyte GSH-Px, and plasma lipid peroxidation of HCF diet rats towards the values of normal rats. |
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Authors:
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Patricia Matanjun; Suhaila Mohamed; Kharidah Muhammad; Noordin Mohamed Mustapha |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal food Volume: 13 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 792-800 Citation Subset: IM |
Affiliation:
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Functional Food Laboratory, Faculty of Food Science and Technology, School of Food Science and Nutrition, University of Putra Malaysia, Serdang, Selangor, Malaysia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Agents / administration & dosage* Caulerpa / chemistry* Cholesterol / administration & dosage*, blood Dietary Fats / administration & dosage Disease Models, Animal Glutathione Peroxidase / metabolism Humans Hypolipidemic Agents / administration & dosage Lipid Peroxidation / drug effects Male Obesity / diet therapy*, metabolism Plant Preparations / administration & dosage* Rats Rats, Sprague-Dawley Rhodophyta / chemistry* Sargassum / chemistry* Seaweed / chemistry* Triglycerides / blood Tropical Climate |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Dietary Fats; 0/Hypolipidemic Agents; 0/Plant Preparations; 0/Triglycerides; 57-88-5/Cholesterol; EC 1.11.1.9/Glutathione Peroxidase |
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