Document Detail


Comparison of Cardiovascular Parameters and/or Serum Chemistry and Hematology Profiles in Conscious and Anesthetized Rhesus Monkeys (Macaca mulatta).
MedLine Citation:
PMID:  12086436     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The rhesus monkey is often used in pre-clinical research, and such studies frequently involve a variety of anesthetic conditions. Therefore, it is important to determine baseline physiologic blood chemistry and cardiovascular parameters in anesthetized animals to facilitate appropriate comparisons. The present study compares the cardiovascular parameters, hematology, serum chemistry, and blood gas levels of rhesus monkeys anesthetized with pentobarbital, isoflurane, ketamine, and propofol. Hematology, serum chemistry, and blood gas levels were unaffected by the four anesthetic regimens. However, because of its formulation, propofol is inappropriate for use in animals in which changes in tryglycerides will be evaluated. Compared to those in conscious, unrestrained monkeys, heart rates were higher in anesthetized animals, but the rates of anesthetized animals were similar regardless of anesthetic agent used. In contrast, mean arterial blood pressure was lower in animals anesthetized with pentobarbital, propofol, or isoflurane than in the conscious monkeys. However, mean arterial pressure of ketamine-anesthetized monkeys was similar to that of the conscious monkeys.
Authors:
Gary J. Hom; Thomas J. Bach; Dayna Carroll; Michael J. Forrest; Michele A. Mariano; Charlotte E. Trainor; Pei-Ran Wang; D. Euan MacIntyre
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science     Volume:  38     ISSN:  1060-0558     ISO Abbreviation:  Contemp Top Lab Anim Sci     Publication Date:  1999 Mar 
Date Detail:
Created Date:  2002-Jun-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204153     Medline TA:  Contemp Top Lab Anim Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  60-64     Citation Subset:  -    
Affiliation:
Department of Pharmacology, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065.
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