Document Detail


Comparison of the cardioprotective effect of deoxygenated hemoglobin-based oxygen carrier (HBOC) pretreatment and ischemia preconditioning.
MedLine Citation:
PMID:  20597843     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
This study was designed to compare the influence of deoxygenated hemoglobin-based oxygen carrier (HBOC) pretreatment and ischemia preconditioning on cardiac ischemia/reperfusion (I/R) injury. Langendorff-perfused rat hearts were pretreated with 0.1 gHb/dL deoxygenated HBOC or ischemia, then subjected to 50-min warm ischemia and 2-hr reperfusion. The results indicated that deoxygenated HBOC pretreatment and ischemia preconditioning both equally improved the recovery of cardiac function, and reduced the cardiac enzyme release and myocardial histopathological changes as compared to the control group. Therefore our study demonstrated that deoxygenated HBOC pretreatment and ischemia precondition provided equivalent protection to the isolated heart against I/R injury.
Authors:
Zhen You; Tao Li; Chengmin Yang; Hong Wu; Yong Zeng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-05
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  39     ISSN:  1532-4184     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-11     Citation Subset:  IM    
Affiliation:
Department of Hepato-Bilio-Pancreatology, West China Hospital, Sichuan University, Chengdu, China.
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