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Comparison of the Cardiac MicroPET Images Obtained Using [(18)F]FPTP and [(13)N]NH3 in Rat Myocardial Infarction Models.
MedLine Citation:
PMID:  25313324     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The short half-life of current positron emission tomography (PET) cardiac tracers limits their widespread clinical use. We previously developed a (18)F-labeled phosphonium cation, [(18)F]FPTP, that demonstrated sharply defined myocardial defects in a corresponding infarcted myocardium. The aim of this study was to compare the image properties of PET scans obtained using [(18)F]FPTP with those obtained using [(13)N]NH3 in rat myocardial infarction models. Perfusion abnormality was analyzed in 17 segments of polar map images. The myocardium-to-liver and myocardium-to-lung ratios of [(18)F]FPTP were 10.48 and 2.65 times higher, respectively, than those of [(13)N]NH3 in images acquired 30 min after tracer injection. The myocardial defect size measured by [(18)F]FPTP correlated more closely with the hypoperfused area measured by quantitative 2,3,5-triphenyltetrazolium chloride staining (r = 0.89, P < 0.01) than did [(13)N]NH3 (r = 0.84, P < 0.01). [(18)F]FPTP might be useful as a replacement for the myocardial agent [(13)N]NH3 in cardiac PET/CT applications.
Dong-Yeon Kim; Hyeon Sik Kim; Hwa Youn Jang; Ju Han Kim; Hee-Seung Bom; Jung-Joon Min
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Publication Detail:
Type:  Journal Article     Date:  2014-09-10
Journal Detail:
Title:  ACS medicinal chemistry letters     Volume:  5     ISSN:  1948-5875     ISO Abbreviation:  ACS Med Chem Lett     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-14     Completed Date:  2014-10-14     Revised Date:  2014-10-16    
Medline Journal Info:
Nlm Unique ID:  101521073     Medline TA:  ACS Med Chem Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1124-8     Citation Subset:  -    
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