| Comparison Between Cardiopulmonary Exercise Testing Parameters and Computed Tomography Findings in Patients with Thoracic Sarcoidosis. | |
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MedLine Citation:
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PMID: 21858420 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Cardiopulmonary exercise testing (CPET) is a safe and clinically useful method to assess functional capacity and to follow disease progression and the response to treatment in several clinical conditions. AIM: We set out to determine the relationship between outcome measures of CPET and high-resolution computed tomography (HRCT) findings in thoracic sarcoidosis. METHODS: A cross-sectional study was carried out in which 42 nonsmoking outpatients (22 females; median age = 46.5 years) were evaluated. All the patients underwent pulmonary function tests (PFTs) and CPET. By using CPET, the most probable causes of exercise limitation were separated into respiratory mechanics (n = 25) and cardiovascular (n = 17). By using HRCT, the following patterns were recorded: predominant nodules (n = 18), predominant ground-glass opacity (n = 10), and predominant traction bronchiectasis and honeycombing (n = 14). RESULTS: Although significant differences have been shown for both PFT parameters and CPET results, only the latter were able to distinguish between patients with ground-glass opacity and patients with traction bronchiectasis and honeycombing on HRCT. A statistically significant difference was found for peak VO(2), breathing reserve, and P(A-a)O(2) when patients with predominant traction bronchiectasis and honeycombing were compared to patients with other HRCT patterns (p < 0.0001). There was no statistical difference among the patterns with abnormal CPET and the patterns of abnormalities on HRCT (p > 0.05). CONCLUSION: The functional capacity assessed by CPET was strongly influenced by HRCT patterns in sarcoidosis. Patients with traction bronchiectasis and honeycombing have lower exercise capacity measured by CPET. |
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Authors:
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Agnaldo José Lopes; Sara Lucia Silveira de Menezes; Cristina Márcia Dias; Juliana Flávia de Oliveira; Míriam Raquel Meira Mainenti; Fernando Silva Guimarães |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-20 |
Journal Detail:
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Title: Lung Volume: - ISSN: 1432-1750 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701875 Medline TA: Lung Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Respiratory Physiology, University of the State of Rio de Janeiro, and Rehabilitation Science Graduate Program, Augusto Motta University, Rua Araguaia, 1266, bloco 1/405, Freguesia, Jacarepaguá, 22745-271, Rio de Janeiro, Brazil, phel.lop@uol.com.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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