| Comparison of Atrial and Brain Natriuretic Peptide for the Assessment of Mitral Stenosis. | |
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MedLine Citation:
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PMID: 21600847 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Accurate evaluation of the functional consequences of mitral stenosis (MS) can be difficult. The aim of this study was to evaluate the relationship between both atrial (ANP) and brain natriuretic peptides (BNP) and symptoms, exercise capacity and echocardiographic measures of MS severity. METHODS: Thirty patients with moderate to severe MS and 14 normal controls underwent clinical assessment, exercise stress echocardiography, measurement of ANP and BNP and two years follow up for clinical events. RESULTS: BNP was higher in MS patients than controls (BNP 58 [IQR 34, 93] vs. 16 [14, 25], p<0.0001). There was considerable overlap in exercise capacity and echocardiographic severity between asymptomatic and symptomatic patients. An increase in BNP was associated with a larger left atrial area index (r=0.67, p<0.0001), reduced mitral valve area (r=-0.38, p=0.05) and higher resting pulmonary artery pressure (r=0.47, p=0.008). Increased BNP predicted lower treadmill exercise capacity (AUC=0.82 [95% confidence interval 0.67, 0.97], p=0.004), guideline criteria for intervention (AUC=0.87 [0.74, 0.99], p=0.006) and adverse events during follow up (AUC=0.81 [0.64, 0.99], p=0.03). Associations for ANP in general were similar but slightly weaker, and ANP did not provide additional predictive information to BNP. CONCLUSION: BNP may improve risk stratification of patients with MS, particularly when symptoms are equivocal. |
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Authors:
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Vishal Sharma; Ralph A H Stewart; Irene Zeng; Christopher Raffel; Andrew J Kerr |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-18 |
Journal Detail:
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Title: Heart, lung & circulation Volume: - ISSN: 1444-2892 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100963739 Medline TA: Heart Lung Circ Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Cardiology, Middlemore Hospital, Auckland, New Zealand; College of Medicine, University of Edinburgh, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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