Document Detail

Comparison of the Application of Allogeneic Fibroblast and Autologous Mesh Grafting With the Conventional Method in the Treatment of Third-Degree Burns.
MedLine Citation:
PMID:  22683986     Owner:  NLM     Status:  Publisher    
Wound healing is a multipart process involving different cell types and growth factors. Third-degree burns are usually treated by early excision and skin grafting. Tissue engineering has been developed in this field in response to limitations associated with autografts. Allogeneic fibroblasts on meshed split thickness skin grafts (STSGs) are known to have useful properties in wound healing and can be used to construct a new model of living skin substitute. Fourteen patients were chosen from June 2009 until December 2010 as the sample for this study. After debridement and wound excision, meshed STSG was used to cover the entire wound. Alloskin (allofibroblasts cultured on a combination of silicone and glycosaminoglycan) was applied on one side and petroleum jelly-impregnated gauze (Iran Polymer and Petrochemical Institute) was applied on the other. The healing time, scar formation, and pigmentation score were assessed for the patients. All analyses were undertaken with SPSS 17 software. Alloskin demonstrated good properties compared to petroleum jelly-impregnated gauze. The average healing time and hypertrophic scar formation were significantly different between the two groups. In addition, the skin pigmentation score in the alloskin group was closer to normal. Alloskin grafting, including fibroblasts on meshed STSG, may be a useful method to reduce healing time and scar size and may require less autologous STSG in extensive burns where a high percentage of skin is burned and there is a lack of available donor sites.
Hamideh Moravvej; Abdoljalil Kalantar Hormozi; Seyed Nejat Hosseini; Rahim Sorouri; Naser Mozafari; Mohammad Reza Ghazisaidi; Mahnaz Mahmoudi Rad; Mohammad Hossein Moghimi; Shahin Mohammad Sadeghi; Hamid Mirzadeh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-7
Journal Detail:
Title:  Journal of burn care & research : official publication of the American Burn Association     Volume:  -     ISSN:  1559-0488     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262774     Medline TA:  J Burn Care Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the *Skin Research Center and † Plastic and Reconstructive Surgery Department, Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; ‡Surgery Department, Ayatollah Mousavi Hospital, §Microbiology Department, and ║Surgery Department, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran; and ¶Polymeric Biomaterials Department, Iran Polymer and Petrochemical Institute (IPPI), Tehran, Iran.
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