Document Detail

A comparison of antibacterial activity against Methicillin-Resistant Staphylococcus aureus and gram-negative organisms for antimicrobial compounds in a unique composite wound dressing.
MedLine Citation:
PMID:  20729646     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Antibiotic resistance is increasing among organisms that commonly cause wound infections. Therefore, it becomes increasingly desirable to prevent wound infections as systemic antibiotic treatment of established wound infections becomes more difficult, more expensive, and potentially more toxic. The ability to incorporate antimicrobial compounds into modern wound dressings provides an opportunity to prevent wound infections without the risk of systemic toxicity, thus diminishing morbidity, mortality, and cost to the healthcare system. DESIGN: In these studies, the authors tested 16 antimicrobial agents in a unique composite wound dressing (TheraGauze; Soluble Systems, LLC, Newport News, Virginia) against clinical methicillin-resistant Staphylococcus aureus isolates and Gram-negative organisms commonly associated with wound infections and antibiotic resistance. Disk diffusion susceptibility testing is used to quantify antimicrobial activity. RESULTS: Broad-spectrum antimicrobial activity was found for the following agents in the composite wound dressing: hydrogen peroxide, tobramycin, chlorhexidine digluconate, chlorhexidine gluconate, levofloxacin, and silver. CONCLUSION: These studies suggest that potent local antibacterial activity can be achieved with several antimicrobials in this wound dressing.
Charlene G Echague; Pamela S Hair; Kenji M Cunnion
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Advances in skin & wound care     Volume:  23     ISSN:  1538-8654     ISO Abbreviation:  Adv Skin Wound Care     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100911021     Medline TA:  Adv Skin Wound Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  406-13     Citation Subset:  N    
Eastern Virginia Medical School, Norfolk, Virginia, USA.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage,  pharmacology*
Disk Diffusion Antimicrobial Tests
Drug Resistance, Bacterial*
Gram-Negative Bacteria / drug effects*
Methicillin-Resistant Staphylococcus aureus / drug effects*
Silver Compounds / pharmacology*
Wound Infection / prevention & control*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Silver Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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