Document Detail

Comparison of the analgesic effects of dexketoprofen and diclofenac during shockwave lithotripsy: a randomized, double-blind clinical trial.
MedLine Citation:
PMID:  20367114     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: This prospective, randomized, and double-blind clinical study aimed to assess the analgesic efficacy of single-dose intramuscular (IM) injection of dexketoprofen (group DE) compared with single-dose IM injection of diclofenac (group DI) in patients who were undergoing shockwave lithotripsy (SWL).
PATIENTS AND METHODS: A total of 70 men with single renal or ureteral stones were randomly separated into two groups. The 40 men in group DI received 75 mg IM diclofenac sodium and 30 men in Group DE received 50 mg IM dexketoprofen trometamol 30 minutes before SWL. A 10-point visual analog scale was used to evaluate pain.
RESULTS: The age, body mass index, and mean stone burden were comparable between the two groups (P > 0.05). The mean visual analog scale score for group DE was statistically lower compared with the score for group DI (P = 0.02). In 34 (85%) of the 40 men in group DI, the SWL procedure was performed with no, minor, or tolerable pain. In group DE, however, 28 (93.3%) of 30 patients evaluated the pain severity as no, minor, or tolerable (p = 0.01). No major/minor adverse effects were observed in group DI, whereas in one patient in group DE, dyspepsia after injection was noticed (P = 0.423).
CONCLUSIONS: The severity of SWL-related pain was significantly better tolerated with dexketoprofen trometamol. During an SWL procedure, the analgesic efficacy of dexketoprofen was greater than that of diclofenac sodium. Although statistically insignificant, a little increased risk for gastric irritation was noticed with dexketoprofen.
Husnu Tokgoz; Serhan Yurtlu; Volkan Hanci; Ozlem Turksoy; Bulent Erol; Bulent Akduman; Aydin Mungan
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of endourology / Endourological Society     Volume:  24     ISSN:  1557-900X     ISO Abbreviation:  J. Endourol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-15     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8807503     Medline TA:  J Endourol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1031-5     Citation Subset:  IM    
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MeSH Terms
Analgesics / therapeutic use*
Diclofenac / therapeutic use*
Double-Blind Method
Ketoprofen / analogs & derivatives*,  therapeutic use
Lithotripsy / adverse effects*,  methods*
Middle Aged
Pain / drug therapy*,  etiology*
Pain Measurement
Tromethamine / analogs & derivatives*,  therapeutic use
Young Adult
Reg. No./Substance:
0/Analgesics; 023C2WHX2V/Tromethamine; 144O8QL0L1/Diclofenac; 90Y4QC304K/Ketoprofen; N674F7L21E/dexketoprofen trometamol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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