Document Detail

Comparison of 99mTc-tetrofosmin uptakes on planar images with those in excised rats organs.
MedLine Citation:
PMID:  11355779     Owner:  NLM     Status:  MEDLINE    
METHODS: Thirty-three rats were imaged at 5, 10, 15, 30, 45, 60, 90 and 120 min after the administration of 99mTc-tetrofosmin, and % injected dose per pixel (%ID/pixel) for each organ was assessed on planar images (PI measurement). Percent injected dose per gram of tissue (%ID/g) in the heart as well as lungs, liver, gastrointestines and blood was measured by means of a well scintillation counter (WC measurement). Comparison between PI and WC measurements was performed with % uptake, the PI-to-WC ratio and heart-to-organ ratios.
RESULTS: Our WC measurement showed an increase in cardiac uptake until 30 min (1.67 +/- 0.31%) postinjection and subsequent gradual decrease, whereas PI measurement showed maximum activity of 1.81 +/- 0.52% at 15 min postinjection. There was a prominent difference between the two measurements, particularly at 10 min, with a PI/WC ratio of about 1.6 times. Our WC measurement showed maximum pulmonary uptake at 15 min (0.87 +/- 0.31%) and a gradual decrease over 15 min, whereas PI measurement showed maximum uptake at 10 min (1.14 +/- 0.38%). There was hardly any variation in activity observed later than at 10 min. Our WC measurement showed hardly any variance in hepatic activity from 5 min (0.77 +/- 0.19%) to 30 min (0.69 +/- 0.27%) with a subsequent gradual decrease. The percent uptake in PI measurement was generally greater than that in WC measurement, and high values were found at 10 min and 15 min with PI/WC ratios of about 3.3 times and 2.3 times, respectively.
CONCLUSION: Percent uptakes in PI measurement were greater than those in WC measurement. The difference between the two measurements was prominent in the early phases. The cardiac uptake in PI measurement was significantly greater than that in WC measurement at 10 min. It was considered that this discrepancy between the two measurements was caused by the Compton scatter from the organs adjacent to the heart.
M Onoguchi; T Takayama; N Tonami; S Kyogoku; Y Naoi; M Irimoto; T Maehara
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  15     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-05-17     Completed Date:  2001-09-27     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  33-40     Citation Subset:  IM    
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MeSH Terms
Heart / radionuclide imaging
Liver / metabolism,  radionuclide imaging
Lung / metabolism,  radionuclide imaging
Myocardium / metabolism
Organophosphorus Compounds / pharmacokinetics*
Organotechnetium Compounds / pharmacokinetics*
Radiopharmaceuticals / pharmacokinetics
Rats, Inbred Strains
Tissue Distribution
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

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