Document Detail


Comparison of 68Ga DOTATATE to 18F-FDG Uptake Is Useful in the Differentiation of Residual or Recurrent Pituitary Adenoma From the Remaining Pituitary Tissue After Transsphenoidal Adenomectomy.
MedLine Citation:
PMID:  24873787     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: The evaluation of the remaining pituitary tissue and recurrent or residual tumor after the pituitary adenoma resection is difficult. However, it is essential to assess the size of the recurrent tumor and remaining pituitary reserve before resurgery. This study aimed to distinguish the remaining pituitary tissue from pituitary adenoma with Ga 1,4,7,10-tetraazacyclododecane-N,N',N″,N″'-tetraacetic acid-D-Phe,Tyr3-octreotate (DOTATATE) and F-FDG PET imaging in patients status post transsphenoidal adenomectomy.
METHODS: Thirty-five patients with suspected recurrent/residual pituitary tumors were retrospectively evaluated. All of these patients underwent DOTATATE and FDG PET/CT within 1 week before additional surgery. The DOTATATE and FDG uptake levels were compared. The image findings were then compared with pathology results after the additional surgery.
RESULTS: Residual or recurrent pituitary adenoma were confirmed pathologically in all 35 patients. One recurrent pituitary adenoma did not have either DOTATATE or FDG uptake. In the remaining 34 adenomas, 33 had higher FDG uptake than DOTATATE uptake. In comparison, DOTATATE had significant higher uptake than FDG in the remaining pituitary tissues in all cases.
CONCLUSIONS: Different degree of uptake of Ga DOTATATE and F-FDG PET/CT in the remaining pituitary tissue and recurrent/residual pituitary tumor indicated that combined analysis of Ga DOTATATE and F-FDG PET/CT might be of clinical value in differentiating recurrent/residual pituitary adenoma from the remaining pituitary tissue.
Authors:
Xiaobin Zhao; Jianqi Xiao; Bing Xing; Renzhi Wang; Zhaohui Zhu; Fang Li
Related Documents :
25103267 - Magic angle-enhanced mri of fibrous microstructures in sclera and cornea with and witho...
23716457 - Temperature-induced changes of magnetic resonance relaxation times in the human brain: ...
22994147 - Magnetic resonance imaging features of sinonasal disorders in horses.
23682307 - An mri-based attenuation correction method for combined pet/mri applications.
24259437 - Performance of gadoxetic acid-enhanced mri for detecting hepatocellular carcinoma in re...
23338667 - Correlation of womac and koos scores to tibiofemoral cartilage loss on plain radiograph...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-28
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  -     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Validation of IAEA Software Package for the Analysis of Scintigraphic Renal Dynamic Studies: Paramet...
Next Document:  FDG PET for Diagnosing Infection in Hip and Knee Prostheses: Prospective Study in 221 Prostheses and...