Document Detail

Comparison of 50 microg and 25 microg doses of intrathecal morphine on postoperative analgesic requirements in patients undergoing transurethral resection of the prostate with intrathecal anesthesia.
MedLine Citation:
PMID:  20650378     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To compare the efficacy of 50 mug and 25 mug doses of intrathecal morphine on postoperative pain in patients undergoing transurethral resection of the prostate (TURP) with low-dose bupivacaine. DESIGN: Randomized, double-blinded study. SETTING: Konya Hospital. PATIENTS: 70 ASA physical status I, II, and III patients. INTERVENTIONS: Patients were randomized to two groups: Group A patients received 5 mg of 0.5% hyperbaric bupivacaine (one mL) and 50 mug of morphine (0.5 mL). Group B patients received 5 mg of 0.5% hyperbaric bupivacaine (one mL) and 25 mug of morphine (0.5 mL). MEASUREMENTS: Postoperative pain scores, patient and surgeon satisfaction, and side effects such as emesis, pruritus, and respiratory depression, were recorded. MAIN RESULTS: Postoperative pain characteristics were similar between the two groups. Frequency of emesis was similar between the groups, while pruritus was significantly higher in Group A. No antipruritic medication was required in any patient. Patient and surgeon satisfaction was evaluated as good or excellent in both groups. CONCLUSIONS: Intrathecal morphine at a dose of 25 mug provides similar postoperative analgesia and less pruritus than the 50 mug dose in patients undergoing TURP.
Ates Duman; Seza Apiliogullari; Mehmet Balasar; Recai Gürbüz; Murat Karcioglu
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  22     ISSN:  1873-4529     ISO Abbreviation:  J Clin Anesth     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-33     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Selcuklu Medical Faculty, Department of Anesthesiology, Selcuk University, Konya, Turkey.
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MeSH Terms
Analgesics, Opioid / administration & dosage*,  adverse effects,  therapeutic use
Anesthetics, Local / administration & dosage,  therapeutic use
Bupivacaine / administration & dosage,  therapeutic use
Dose-Response Relationship, Drug
Double-Blind Method
Injections, Spinal
Middle Aged
Morphine / administration & dosage*,  adverse effects,  therapeutic use
Pain, Postoperative / prevention & control
Patient Satisfaction
Prospective Studies
Transurethral Resection of Prostate / methods*
Vomiting / chemically induced
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Local; 2180-92-9/Bupivacaine; 57-27-2/Morphine

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