| Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model. | |
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MedLine Citation:
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PMID: 21496535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Plant-based intravenous lipid emulsions have been shown to contribute to parenteral nutrition-associated liver disease (PNALD). There is mounting evidence that fish oil-based emulsions may prevent this liver injury. This study compares 5 emulsions with different fat compositions and their effect on hepatic steatosis, one of the first hits in PNALD. METHODS: C57BL/6J mice were placed on a fat-free diet and randomized into 5 equal groups. Each group received one of the commercially available intravenous lipid emulsions (Intralipid [Baxter/Fresenius Kabi, Deerfield, Ill], Liposyn II [Hospira Inc, Lake Forest, Ill], ClinOleic [Baxter/Clintec Parenteral SA, Cedex, France], SMOFlipid [Fresenius Kabi, Bad Homburg, Germany], or Omegaven [Fresenius Kabi Deutschland GmbH]) or normal saline. Liver enzymes, degree of steatosis, and fatty acid compositions were analyzed after 19 days. RESULTS: Intralipid, Liposyn II, ClinOleic, and SMOFlipid groups all demonstrated moderate steatosis with hepatic fat contents of 17.4%, 21.9%, 22.5%, and 12.6%, respectively. Omegaven mice, however, had normal livers. Saline control mice developed biochemical evidence of essential fatty acid deficiency (EFAD). Lipid supplementation with Intralipid, Liposyn II, and Omegaven prevented the onset of biochemical EFAD, whereas administration of ClinOleic and SMOFlipid did not. CONCLUSION: The fish oil-based lipid emulsion Omegaven prevented hepatic steatosis and EFAD in this murine model. ω-3 fatty acids may be efficacious in preventing PNALD and should be explored in the development of novel lipid emulsions. |
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Authors:
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Jonathan A Meisel; Hau D Le; Vincent E de Meijer; Vania Nose; Kathleen M Gura; Robert V Mulkern; M Reza Akhavan Sharif; Mark Puder |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 46 ISSN: 1531-5037 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-08-16 Revised Date: 2012-02-23 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 666-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Surgery and the Vascular Biology Program, Children's Hospital Boston, Boston, MA 02115, USA. jmeisel@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholestasis / complications, therapy* Disease Models, Animal Emulsions / administration & dosage Fat Emulsions, Intravenous / administration & dosage* Liver Failure / etiology, prevention & control* Mice Mice, Inbred C57BL Parenteral Nutrition / methods* Phospholipids / administration & dosage* Soybean Oil / administration & dosage* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Emulsions; 0/Fat Emulsions, Intravenous; 0/Phospholipids; 0/soybean oil, phospholipid emulsion; 8001-22-7/Soybean Oil |
| Comments/Corrections | |
Erratum In:
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J Pediatr Surg. 2012 Jan;47(1):272 |
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