Document Detail

Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy.
MedLine Citation:
PMID:  18325699     Owner:  NLM     Status:  MEDLINE    
Topical photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an alternative therapy for many non-melanoma skin cancers. The major limitation of this therapy, however, is the low permeability of ALA through the stratum corneum (SC) of the skin. The objective of the present work was to characterize ethosomes containing ALA and to enhance the skin production of protoporphyrin IX (PpIX), compared to traditional liposomes. Results showed that the average particle sizes of the ethosomes were less than those of liposomes. Moreover, the entrapment efficiency of ALA in the ethosome formulations was 8-66% depending on the surfactant added. The particle size of the ethosomes was still approximately <200 nm after 32 days of storage. An in vivo animal study observed the presence of PpIX in the skin by confocal laser scanning microscopy (CLSM). The results indicated that the penetration ability of ethosomes was greater than that of liposomes. The enhancements of all the formulations were ranging from 11- to 15-fold in contrast to that of control (ALA in an aqueous solution) in terms of PpIX intensity. In addition, colorimetry detected no erythema in the irradiated skin. The results demonstrated that the enhancement ratio of ethosome formulations did not significantly differ between the non-irradiated and irradiated groups except for PE/CH/SS, which may have been due to a photobleaching effect of the PDT-irradiation process.
Yi-Ping Fang; Yi-Hung Tsai; Pao-Chu Wu; Yaw-Bin Huang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-19
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  356     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-29     Completed Date:  2008-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  144-52     Citation Subset:  IM    
Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
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MeSH Terms
Aminolevulinic Acid / administration & dosage*,  adverse effects,  pharmacokinetics
Chemistry, Pharmaceutical
Drug Stability
Drug Storage
Ethanol / chemistry*
Mice, Inbred ICR
Mice, Nude
Particle Size
Photosensitizing Agents / administration & dosage*,  adverse effects,  pharmacokinetics
Protoporphyrins / metabolism
Skin Absorption
Skin Neoplasms / drug therapy
Surface-Active Agents / chemistry
Reg. No./Substance:
0/Liposomes; 0/Photosensitizing Agents; 0/Protoporphyrins; 0/Surface-Active Agents; 106-60-5/Aminolevulinic Acid; 553-12-8/protoporphyrin IX; 64-17-5/Ethanol

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