| Comparison of 2 moxifloxacin regimens for preoperative prophylaxis: prospective randomized triple-masked trial. Part 1: aqueous concentration of moxifloxacin. | |
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MedLine Citation:
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PMID: 18655991 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the aqueous concentration of moxifloxacin following 2 dosing regimens of topically administered moxifloxacin hydrochloride ophthalmic solution 0.5% (Vigamox). SETTING: Iladevi Cataract & IOL Research Centre, Ahmedabad, India. METHODS: In this prospective randomized triple-masked clinical trial, 156 patients having cataract surgery were randomly assigned to 1 of 2 regimens of preoperative prophylaxis. In Group A (n = 76), Vigamox was instilled 4 times a day 1 day before surgery plus 1 drop 2 hours before surgery (total of 5 drops). In Group B (n = 76), Vigamox was first instilled 2 hours before surgery and then every 15 minutes for 1 hour (total of 5 drops). In both groups, aqueous samples (0.1 mL) were collected within 2 hours of the first instillation on the day of surgery and stored at -80 degrees C. The antibiotic concentration in all aqueous aspirates was determined using high-performance liquid chromatography. Data were analyzed using the Kolmogorov-Smirnov t test; 95% confidence intervals (CIs) were calculated. RESULTS: The mean aqueous humor concentration of moxifloxacin was 1.58 microg/mL +/- 0.80 (SD) in Group A and 2.05 +/- 0.72 microg/mL in Group B (P<.0001; 95% CI, -0.72 to -0.22). CONCLUSIONS: Both dosing regimens produced substantially higher aqueous concentrations than the known minimum inhibitory concentration for Staphylococcus epidermidis. Topical moxifloxacin administered 2 hours before surgery achieved significantly higher aqueous concentrations than topical moxifloxacin administered 1 day before surgery with 1 drop given on the day of surgery. |
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Authors:
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Abhay R Vasavada; Devarshi Gajjar; Shetal M Raj; Vaishali Vasavada; Viraj Vasavada |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cataract and refractive surgery Volume: 34 ISSN: 0886-3350 ISO Abbreviation: J Cataract Refract Surg Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-09-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8604171 Medline TA: J Cataract Refract Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1379-82 Citation Subset: IM |
Affiliation:
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Iladevi Cataract & IOL Research Centre, Raghudeep Eye Clinic, Memnagar, Ahmedabad, India. icirc@abhayvasavada.com <icirc@abhayvasavada.com> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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administration & dosage,
pharmacokinetics* Antibiotic Prophylaxis* Aqueous Humor / metabolism* Aza Compounds / administration & dosage, pharmacokinetics* Biological Availability Cataract Extraction* Chromatography, High Pressure Liquid Epidemiologic Methods Female Humans Male Middle Aged Ophthalmic Solutions / administration & dosage, pharmacokinetics* Prospective Studies Quinolines / administration & dosage, pharmacokinetics* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Aza Compounds; 0/Ophthalmic Solutions; 0/Quinolines; 0/moxifloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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