| Comparison of (18)F-fluorothymidine and (18)F-fluorodeoxyglucose PET/CT in delineating gross tumor volume by optimal threshold in patients with squamous cell carcinoma of thoracic esophagus. | |
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MedLine Citation:
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PMID: 19910143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the optimal method of using (18)F-fluorothymidine (FLT) positron emission tomography (PET)/computed tomography (CT) simulation to delineate the gross tumor volume (GTV) in esophageal squamous cell carcinoma verified by pathologic examination and compare the results with those using (18)F-fluorodeoxyglucose (FDG) PET/CT. METHODS AND MATERIALS: A total of 22 patients were enrolled and underwent both FLT and FDG PET/CT. The GTVs with biologic information were delineated using seven different methods in FLT PET/CT and three different methods in FDG PET/CT. The results were compared with the pathologic gross tumor length, and the optimal threshold was obtained. Next, we compared the simulation plans using the optimal threshold of FLT and FDG PET/CT. The radiation dose was prescribed as 60 Gy in 30 fractions with a precise radiotherapy technique. RESULTS: The mean +/- standard deviation pathologic gross tumor length was 4.94 +/- 2.21 cm. On FLT PET/CT, the length of the standardized uptake value 1.4 was 4.91 +/- 2.43 cm. On FDG PET/CT, the length of the standardized uptake value 2.5 was 5.10 +/- 2.18 cm, both of which seemed more approximate to the pathologic gross tumor length. The differences in the bilateral lung volume receiving > or =20 Gy, heart volume receiving > or =40 Gy, and the maximal dose received by spinal cord between FLT and FDG were not significant. However, the values for mean lung dose, bilateral lung volume receiving > or =5, > or =10, > or =30, > or =40, and > or =50 Gy, mean heart dose, and heart volume receiving > or =30 Gy using FLT PET/CT-based planning were significant lower than those using FDG PET/CT. CONCLUSION: A standardized uptake value cutoff of 1.4 on FLT PET/CT and one of 2.5 on FDG PET/CT provided the closest estimation of GTV length. Finally, FLT PET/CT-based treatment planning provided potential benefits to the lungs and heart. |
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Authors:
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Dali Han; Jinming Yu; Yonghua Yu; Guifang Zhang; Xiaojun Zhong; Jie Lu; Yong Yin; Zheng Fu; Dianbin Mu; Baijiang Zhang; Wei He; Zhijun Huo; Xijun Liu; Lei Kong; Shuqiang Zhao; Xiangyu Sun |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-11-10 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 76 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 1235-41 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province 250117, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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pathology,
radiography,
radionuclide imaging*,
radiotherapy Dideoxynucleosides / diagnostic use Dose Fractionation Esophageal Neoplasms / pathology, radiography, radionuclide imaging*, radiotherapy Female Fluorodeoxyglucose F18 / diagnostic use Heart / radiation effects Humans Lung / radiation effects Lymph Node Excision Male Positron-Emission Tomography / methods* Prospective Studies Radiopharmaceuticals / diagnostic use Spinal Cord / radiation effects Tomography, X-Ray Computed / methods* Tumor Burden* |
| Chemical | |
Reg. No./Substance:
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0/Dideoxynucleosides; 0/Radiopharmaceuticals; 25526-93-6/alovudine; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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