| Comparison of 18F-FDG-PET and standard procedures for the pretreatment staging of children and adolescents with Hodgkin's disease. | |
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MedLine Citation:
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PMID: 16565847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to perform a prospective, blinded comparison of( 18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) and conventional staging methods (CSMs) for initial staging of children and adolescents with Hodgkin's disease (HD). METHODS: Over a period of 4 years, 55 children and adolescents with HD (mean age 15.5 years, range 3.9-18.9 years) were prospectively recruited into the study. They underwent 61 FDG-PET studies using a dedicated whole-body PET scanner as a part of their initial staging work-up. PET findings were correlated with the results of CSMs, including computed tomography (CT), ultrasound, bone scanning and bone marrow examination. Discordant findings were resolved by magnetic resonance imaging or clinical follow-up (range 2-47 months). RESULTS: PET correctly changed the staging in 15% of patients (seven upstagings, two downstagings). Only two out of 61 patients (3%) were not accurately staged by PET; in these children, PET missed small lymphoma nodules detected on lung CT. The sensitivity of PET and CSMs for pretreatment staging was 96.5% and 87.5%, respectively; specificity was 100% and 60%, and accuracy, 96.7% and 85.2%, respectively. Upon combination of FDG-PET and lung CT, the diagnostic accuracy reached 100% in our series. CONCLUSION: Our study showed that whole-body FDG-PET is an efficient and useful method for the initial staging of children with HD. FDG-PET in combination with lung CT should be recommended as a screening method prior to other conventional imaging modalities to plan a rational staging protocol. Large multicentre prospective studies are necessary to verify this conclusion. |
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Authors:
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Edita Kabickova; David Sumerauer; Eliska Cumlivska; Eva Drahokoupilova; Michaela Nekolna; Marketa Chanova; Marie Hladikova; Roman Kodet; Otakar Belohlavek |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-25 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 33 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-14 Completed Date: 2007-04-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 1025-31 Citation Subset: IM |
Affiliation:
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Department of Paediatric Haematology and Oncology, Charles University 2nd Medical School, V Uvalu 84, 150 06 Prague 5, Czech Republic. edita.kabickova@lfmotol.cuni.cz |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Female Fluorine Radioisotopes / diagnostic use Fluorodeoxyglucose F18 / diagnostic use* Hodgkin Disease / pathology*, radiography, radionuclide imaging* Humans Lung / radiography Male Neoplasm Staging / methods* Positron-Emission Tomography Prospective Studies Radiopharmaceuticals / diagnostic use* Single-Blind Method Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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