| Comparison of 15:1, 15:2, and 30:2 compression-to-ventilation ratios for cardiopulmonary resuscitation in a canine model of a simulated, witnessed cardiac arrest. | |
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MedLine Citation:
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PMID: 18275449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This experimental study compared the effect of compression-to-ventilation (CV) ratios of 15:1, 15:2, and 30:2 on hemodynamics and resuscitation outcome in a canine model of a simulated, witnessed ventricular fibrillation (VF) cardiac arrest. METHODS: Thirty healthy dogs, irrespective of species (mean +/- SD, 19.2 +/- 2.2 kg), were used in this study. A VF arrest was induced. The dogs received cardiopulmonary resuscitation (CPR) and were divided into three groups based on the applied CV ratios of 15:1, 15:2, and 30:2. After 1 minute of untreated VF, 4 minutes of basic life support (BLS) was performed. At the end of the 4 minutes, the dogs were defibrillated with an automatic external defibrillator (AED) and advanced cardiac life support (ACLS) efforts were continued for 10 minutes or until restoration of spontaneous circulation (ROSC) was attained, whichever came first. RESULTS: None of the hemodynamic parameters, and arterial oxygen profiles was significantly different between the three groups during BLS- and ACLS-CPR. Eight dogs (80%) from each group achieved ROSC during BLS and ACLS. The survival rate was not different between the three groups. In the 15:1 and 30:2 groups, the number of compressions delivered over 1 minute were significantly greater than in the 15:2 group (73.1 +/- 8.1 and 69.0 +/- 6.9 to 56.3 +/- 6.8; p < 0.01). The time for ventilation during which compressions were stopped at each minute was significantly lower in the 15:1 and 30:2 groups than in the 15:2 group (15.4 +/- 3.9 and 17.1 +/- 2.7 to 25.2 +/- 2.6 sec/min; p < 0.01). CONCLUSIONS: In a canine model of witnessed VF using a simulated scenario, CPR with three CV ratios, 15:1, 15:2, and 30:2, did not result in any differences in hemodynamics, arterial oxygen profiles, and resuscitation outcome among the three groups. CPR with a CV ratio of 15:1 provided comparable chest compressions and shorter pauses for ventilation between each cycle compared to a CV ratio of 30:2. |
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Authors:
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Sung Oh Hwang; Sun Hyu Kim; Hyun Kim; Yong Soo Jang; Pei Ge Zhao; Kang Hyun Lee; Han Joo Choi; Tae Yong Shin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Volume: 15 ISSN: 1553-2712 ISO Abbreviation: Acad Emerg Med Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-15 Completed Date: 2008-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9418450 Medline TA: Acad Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 183-9 Citation Subset: IM |
Affiliation:
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Wonju College of Medicine, Yonsei University, Wonju, Kangwondo, Republic of Korea. shwang@yonsei.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Cardiopulmonary Resuscitation / methods* Disease Models, Animal Dogs Heart Arrest / blood, etiology, therapy* Heart Massage Respiration, Artificial Ventricular Fibrillation / blood, complications |
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