Document Detail

Comparison of 1.5 and 3.0 T for contrast-enhanced pulmonary magnetic resonance angiography.
MedLine Citation:
PMID:  21993980     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In a recent multi-center trial of gadolinium contrast-enhanced magnetic resonance angiography (Gd-MRA) for diagnosis of acute pulmonary embolism (PE), two centers utilized a common MRI platform though at different field strengths (1.5T and 3T) and realized a signal-to-noise gain with the 3T platform. This retrospective analysis investigates this gain in signal-to-noise of pulmonary vascular targets.
METHODS: Thirty consecutive pulmonary MRA examinations acquired on a 1.5T system at one institution were compared to 30 consecutive pulmonary MRA examinations acquired on a 3T system at a different institution. Both systems were from the same MRI manufacturer and both used the same Gd-MRA pulse sequence, although there were some protocol adjustments made due to field strength differences. Region-of-interests were manually defined on the main pulmonary artery, 4 pulmonary veins, thoracic aorta, and background lung for objective measurement of signal-to-noise, contrast-to-noise, and bolus timing bias between centers.
RESULTS: The 3T pulmonary MRA protocol achieved higher spatial resolution yet maintained significantly higher signal-to-noise ratio (≥13%, p = 0.03) in the main pulmonary vessels relative to 1.5T. There was no evidence of operator bias in bolus timing or patient hemodynamic differences between groups.
CONCLUSION: Relative to 1.5T, higher spatial resolution Gd-MRA can be achieved at 3T with a sustained or greater signal-to-noise ratio of enhanced vasculature.
Frank Joseph Londy; Suzan Lowe; Paul D Stein; John G Weg; Robert L Eisner; Kenneth V Leeper; Pamela K Woodard; H Dirk Sostman; Kathleen A Jablonski; Sarah E Fowler; Charles A Hales; Russell D Hull; Alexander Gottschalk; David P Naidich; Thomas L Chenevert
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-10-12
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  18     ISSN:  1938-2723     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-07-16     Revised Date:  2013-07-17    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-9     Citation Subset:  IM    
Department of Radiology, University of Michigan, Ann Arbor, 48109, USA.
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MeSH Terms
Aorta, Thoracic / pathology
Clinical Trials, Phase III as Topic / statistics & numerical data
Contrast Media
Gadolinium / diagnostic use
Image Enhancement
Lung / blood supply*
Magnetic Fields
Magnetic Resonance Angiography / instrumentation*,  methods
Multicenter Studies as Topic / statistics & numerical data
Pulmonary Artery / pathology
Pulmonary Embolism / diagnosis*,  pathology
Pulmonary Veins / pathology
Retrospective Studies
Signal-To-Noise Ratio
Grant Support
Reg. No./Substance:
0/Contrast Media; 7440-54-2/Gadolinium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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