Document Detail

Comparison of 11C-methionine PET and 18F-fluorodeoxyglucose PET in differentiated thyroid cancer.
MedLine Citation:
PMID:  18753824     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this prospective study is to evaluate the possibility of 11C-methionine (Met) PET compared with 18F-fluorodeoxyglucose (FDG) PET for the detection of recurrent or metastatic disease in patients with differentiated thyroid cancer (DTC). MATERIALS AND METHODS: Twenty patients with clinical suspicion of recurrent DTC but negative posttreatment 131I-whole body scans were included in the study. Both 11C-Met PET and 18F-FDG PET were performed within 1 week. PET images were analyzed by two independent and blinded physicians using visual and standardized uptake value analysis. PET results were also correlated with radiologic and/or cytological investigations. RESULTS: Thirteen patients showed concordant findings on both PET scans: six patients showed uptake and in seven no uptake was observed. In six of the seven patients without Met and FDG uptake, additional MRI and ultrasound-guided fine needle aspiration cytology of the lymph nodes revealed inconclusive or negative results. Six patients showed discordant findings on the PET scans: in three patients uptake was only observed on the Met PET, confirmed by MRI in one. In three patients lesions were seen on the FDG PET, confirmed by computed tomography or ultrasound-guided fine needle aspiration cytology. However, those lesions were not compatible with the lesions seen on the Met PET. In general, FDG uptake appeared to be higher than Met uptake, but was not significant (P=0.075). CONCLUSION: This study shows that imaging using radiolabeled amino acids is feasible in DTC. For now, 11C-Met PET has not proven to be superior to 18F-FDG PET in the detection of recurrent disease in DTC. Complementary uptake of Met and FDG has, however, been observed, which has to be further clarified and long-term follow-up is needed to define the true clinical value of the 11C-Met PET, and possible other amino acids tracers.
Ha T T Phan; Pieter L Jager; John T M Plukker; Bruce H R Wolffenbuttel; Rudi A Dierckx; Thera P Links
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  29     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-28     Completed Date:  2008-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  711-6     Citation Subset:  IM    
Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University Hospital of Groningen, The Netherlands.
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MeSH Terms
Carbon Radioisotopes
Feasibility Studies
Fluorodeoxyglucose F18 / diagnostic use*
Lymph Nodes / radionuclide imaging
Lymphatic Metastasis
Methionine / diagnostic use*
Middle Aged
Pilot Projects
Positron-Emission Tomography
Prospective Studies
Radiopharmaceuticals / diagnostic use*
Thyroglobulin / metabolism
Thyroid Neoplasms / pathology,  radionuclide imaging*
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Radiopharmaceuticals; 63-68-3/Methionine; 63503-12-8/Fluorodeoxyglucose F18; 9010-34-8/Thyroglobulin

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