| Comparison of (11)C-Choline PET/CT and Enhanced CT in the Evaluation of Patients With Pulmonary Abnormalities and Locoregional Lymph Node Involvement in Lung Cancer. | |
| | |
MedLine Citation:
|
PMID: 22182444 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: This study compares the diagnostic abilities of integrated (11)C-choline PET/CT imaging and contrast-enhanced helical CT imaging in pulmonary lesions and locoregional lymph node metastases in patients with lung cancer. PATIENTS AND METHODS: One hundred eight patients with proven or suspected lung cancer underwent integrated (11)C-choline PET/CT and contrast-enhanced CT, followed by surgical resection and nodal staging. RESULTS: The (11)C-choline PET/CT and CT diagnoses of pulmonary lesions and locoregional lymph node metastases were compared with pathologic findings, which revealed benign lesions in 26 patients (tuberculoma [8 patients], inflammatory pseudotumor [7 patients], hamartoma [6 patients], sclerosing hemangioma [4 patients], and pulmonary sequestration [1 patient]) and lung cancers in 82 patients (adenocarcinoma [39 patients], squamous cell carcinoma [23 patients], carcinoid [7 patients], small-cell lung cancer [5 patients], adenosquamous carcinoma [5 patients], and large-cell lung cancer [3 patients]). The accuracy, sensitivity, and specificity of (11)C-choline PET/CT for diagnosing lung cancer were 82.4%, 85.4%, and 73.1%, respectively, compared with 73.1%, 76.8%, and 61.5%, respectively, for CT. Differences between (11)C-choline PET/CT and CT in diagnosing lung cancer were not statistically significant (p = .503, .118, and .375, respectively). We used receiver operating characteristic (ROC) curve for analysis, finding the ROC of standard uptake value (SUV(max)) for diagnosing lung cancer. The cutoff value of SUV(max) was 3.54. Preoperative nodal staging was compared with postoperative histopathologic staging. (11)C-choline PET/CT correctly staged 80.5% of patients, 12.2% were overstaged, and 7.3% were understaged; for CT these values were 58.5%, 24.4%, and 17.1%, respectively. The accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of (11)C-choline PET/CT for lymph nodes were 83.8%, 82.4%, 84.1%, 50.3%, and 96.1%, respectively, compared with 69.3%, 63.7%, 71.2%, 30.2%, 91.0%, respectively, for CT. CONCLUSION: Differences in the accuracy, sensitivity, specificity, PPV, and NPV between (11)C-choline PET/CT and CT are thus statistically significant for nodal staging (p = .003, .007, .000, .000, and .004, respectively). Although (11)C-choline PET/CT is not significantly better at diagnosing pulmonary lesions than is enhanced CT, (11)C-choline PET/CT has improved sensitivity, specificity, accuracy, PPV, and NPV relative to enhanced CT in the evaluation of locoregional lymph nodes. |
| | |
Authors:
|
Zhongmin Peng; Qingwei Liu; Meng Li; Mingyong Han; Shuzhan Yao; Qi Liu |
Related Documents
:
|
21724124 - Evaluation of ct and mri scanning among cancer patientsin ontario. 15935974 - Opacity transfer function optimization for volume-rendered computed tomography images o... 22221634 - Growth in the use of pet for six cancer types after coverage by medicare: additive or r... 21602734 - Negative predictive value of positron emission tomography/computed tomography in patien... 19959004 - Magnetic resonance perfusion and permeability imaging in brain tumors. 16918964 - Integrated 18f-fdg pet/ct for the initial evaluation of cervical node level of patients... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-17 |
Journal Detail:
|
Title: Clinical lung cancer Volume: - ISSN: 1938-0690 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100893225 Medline TA: Clin Lung Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification, Isolation and characterization of a novel azoreductase from Clostridium perfringens.
Next Document: Adaptive divergence of the moor frog (Rana arvalis) along an acidification gradient.