| Comparison of 10% povidone-iodine and 0.5% chlorhexidine gluconate for the prevention of peripheral intravenous catheter colonization in neonates: a prospective trial. | |
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MedLine Citation:
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PMID: 7667056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the study was to compare the efficacy of 10% povidone-iodine with that of 0.5% chlorhexidine gluconate in 70% isopropyl alcohol for the prevention of peripheral intravenous catheter colonization in neonates. This was a multicenter, nonrandomized prospective study in a tertiary neonatal intensive care setting in which povidone-iodine and chlorhexidine gluconate were each used as antiseptic skin preparations over sequential 6-month periods. During the first 6 months of the study when povidone-iodine was in use 9.3% (38 of 408) of catheters were colonized. During the second 6 months of the study when chlorhexidine gluconate was in use, catheter colonization occurred in 4.7% (20 of 418, P = 0.01). Catheter-related bacteremia occurred during only 0.2% (2 of 826) of all catheterizations. Heavy skin colonization before catheter insertion (relative risk, 3.6; 95% confidence interval, 1.9, 7.0), catheterization > or = 72 hours (relative risk. 2.0; 95% confidence interval, 1.01, 3.8) and gestational age < or = 32 weeks (relative risk, 1.8; 95% confidence interval, 1.02, 3.3) increased colonization risk. Ampicillin infusion (relative risk, 0.4; 95% confidence interval, 0.2, 0.7) and 0.5% chlorhexidine gluconate cutaneous antisepsis (relative risk, 0.4; 95% confidence interval, 0.2, 0.8) were factors associated with decreased colonization risk. We conclude that 0.5% chlorhexidine gluconate in 70% isopropyl alcohol appears to be more efficacious than 10% povidone-iodine for the prevention of peripheral intravenous catheter colonization in neonates. |
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Authors:
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J S Garland; R K Buck; P Maloney; D M Durkin; S Toth-Lloyd; M Duffy; P Szocik; T L McAuliffe; D Goldmann |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 14 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-10-12 Completed Date: 1995-10-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 510-6 Citation Subset: IM |
Affiliation:
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Joint Program in Neonatology, Harvard Medical School, Boston, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Anti-Infective Agents, Local / administration & dosage Antisepsis* Bacteremia / drug therapy, epidemiology, etiology*, prevention & control* Bacteria / growth & development Catheterization, Peripheral / adverse effects* Chlorhexidine / administration & dosage* Colony Count, Microbial Equipment Contamination / prevention & control Female Humans Infant, Newborn Intensive Care Units, Neonatal Logistic Models Male Povidone-Iodine / administration & dosage* Prospective Studies Risk Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 25655-41-8/Povidone-Iodine; 55-56-1/Chlorhexidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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