| Comparing vaginal and buccal misoprostol when used after methotrexate for early abortion. | |
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MedLine Citation:
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PMID: 15541407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The primary objective of this study was to determine if buccal misoprostol was as effective as vaginal misoprostol in medical abortions. The secondary objectives were to compare side effects and acceptability. METHODS: This was a randomized controlled trial of 600 microg misoprostol by the buccal or vaginal routes used 3 to 6 days after 50 mg/m2 methotrexate. The participants were women presenting for abortion at 49 days or less gestation. The outcome measures were the number of women who had aborted by Day 8, side effects and acceptability. RESULTS: Day 8 completion rate was 53.5% for the buccal route and 67.5% for the vaginal route (p = 0.012). Side effects were similar in the two groups except that there was more burning with the buccal route. Overall acceptability and route acceptability were similar in the two groups. CONCLUSIONS: When used after methotrexate for early abortion, the vaginal route for misoprostol is more effective and preferred to the buccal route. |
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Authors:
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Ellen R Wiebe; Konia Trouton |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Contraception Volume: 70 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-15 Completed Date: 2005-04-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 463-6 Citation Subset: IM |
Affiliation:
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Department of Family Practice, University of British Columbia, 1013-750 West Broadway, Vancouver, British Columbia, V5Z 1H9, Canada. ellenwiebe@telus.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage* Abortion, Induced* Administration, Buccal Administration, Intravaginal Adult Female Gestational Age Humans Methotrexate / administration & dosage* Misoprostol / administration & dosage* Pregnancy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate; 59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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