Document Detail

Comparing the pregnancy rates of one versus two intrauterine inseminations (IUIs) in male factor and idiopathic infertility.
MedLine Citation:
PMID:  16496208     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the effectiveness of double IUI with single IUI in male factor and idiopathic infertility patients undergoing controlled ovarian hyperstimulation (COH).
METHODS: A prospective randomized study of 1257 COH-IUI cycles was performed. Total 1270 patients with mild or moderate male factor infertility (n = 776) and idiopathic infertility (n = 494) were enrolled in this study, and 767 with male factor infertility and 490 with idiopathic infertility completed clomiphene citrate (CC)/human menopausal gonadotrophin (hMG) COH cycles and IUI. Categorized on the basis of the causes of infertility (male factor, M; idiopathic infertility, I), patients were randomized into one of the following groups: Single IUI group (M(1)/I(1)) received single insemination 34 h post hCG administration, and double IUI group (M(2)/I(2)) received two inseminations 18-24 and 36-48 h post hCG injection, respectively.
RESULTS: The overall pregnancy rates were 15.43%. Pregnancy rate for single and double IUI group was 11.06 and 19.87% (p < 0.05), respectively. There was a significant statistical difference in cycle fecundity between M(1) and M(2) group (11.34% vs. 24.93%, p < 0.05), and between I(2) and M(2) group (11.93% vs. 24.93%, p < 0.05), but there was no significant difference between I(1) and I(2) (10.53% vs. 11.93%, p > 0.05).
CONCLUSIONS: Double IUI increases the pregnancy rate significantly in patients with male factor infertility, and single IUI acts as efficient as double IUI in patients with idiopathic infertility.
Wei Liu; Fei Gong; Keli Luo; Guangxiu Lu
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2006-02-23
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  23     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2007-01-04     Revised Date:  2013-02-19    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Institute of Human Reproduction and Stem Cell Engineering, Central South University, Changsha, Hunan Province, 410078, PR China.
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MeSH Terms
Infertility, Male*
Insemination, Artificial, Homologous / methods*
Ovulation Induction
Pregnancy Rate*
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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