Document Detail

Comparing intracytoplasmic sperm injection and in vitro fertilization in patients with single oocyte retrieval.
MedLine Citation:
PMID:  17157846     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the efficacy of intracytoplasmic sperm injection (ICSI) and conventional IVF in patients with favorable and poor sperm parameters in which only a single oocyte was available for insemination. DESIGN: Retrospective analysis. SETTING: University-affiliated IVF center. PATIENT(S): A total of 311 patients (425 cycles) who underwent either stimulated or spontaneous IVF cycles that resulted in single oocyte retrieval. INTERVENTION(S): The ICSI was indicated when fertilization failure was anticipated because of sperm quality or other confounding female factors. MAIN OUTCOME MEASURE(S): Fertilization rates and pregnancy rates (PRs) were analyzed according to the woman's age (< or =39 or >39 years), sperm quality, and mode of insemination. RESULT(S): In patients <39 years old with favorable semen quality, ICSI and standard insemination produced similar fertilization rates (67.1% vs. 75.0%) and PRs (0.0 vs. 8.2%). Conversely, in cases with apparent lower semen quality, ICSI gave a significantly higher fertilization rate (85.4% vs. 44.2%) but no significant difference in PRs (14.6% vs. 4.7%). In patients >39 years old and with favorable semen quality, ICSI and standard insemination produced similar fertilization rates (82.4% vs. 68.4%) and PRs (0.0 vs. 1.1%). The ICSI for lower semen quality, however, produced both higher fertilization rates (84.0% vs. 52%) and higher PRs (8.0% vs. 0). CONCLUSION(S): Our results suggest that in poorly responding patients, semen quality should remain the most important determinant when considering whether to perform ICSI. We have found that the values of 20 x 10(6)/mL and 35% motility are good predictors of success in such patients.
Itai Gozlan; Alon Dor; Betty Farber; Dror Meirow; Shira Feinstein; Jacob Levron
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-12-08
Journal Detail:
Title:  Fertility and sterility     Volume:  87     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-03-30     Revised Date:  2007-09-25    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-8     Citation Subset:  IM    
Miller School of Medicine, University of Miami, Miami, Florida, USA.
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MeSH Terms
Embryo Transfer
Fertilization in Vitro / methods*
Middle Aged
Retrospective Studies
Sperm Injections, Intracytoplasmic / methods*
Treatment Outcome
Comment In:
Fertil Steril. 2007 Sep;88(3):754; author reply 754   [PMID:  17681297 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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