Document Detail


Comparing guiding track requirements for myosin- and kinesin-powered molecular shuttles.
MedLine Citation:
PMID:  18636779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The design of nanoscale transport systems utilizing motor proteins as engines has advanced rapidly. Here, actin/myosin- and microtubule/kinesin-based molecular shuttles are compared with respect to their requirements for track designs. To this end, the trajectory persistence length of actin filaments gliding on myosin-coated surfaces has been experimentally determined to be equal to 8.8 +/- 2 microm. This measurement complements an earlier determination of the trajectory persistence length of microtubules gliding on kinesin-coated surfaces and enables a comparison of the accessible track designs for kinesin and myosin motor-powered systems. Despite the 200-fold smaller stiffness of actin filaments compared to that of microtubules, the dimensions of myosin tracks for actin filaments have to be quite similar to the dimensions of kinesin tracks for microtubules (radii larger than 200 nm and widths smaller than 0.9 microm compared to 600 nm and 19 microm). The difference in gliding speed is shown to require additional consideration in the design of track modules.
Authors:
Takahiro Nitta; Akihito Tanahashi; Yu Obara; Motohisa Hirano; Maria Razumova; Michael Regnier; Henry Hess
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-07-18
Journal Detail:
Title:  Nano letters     Volume:  8     ISSN:  1530-6984     ISO Abbreviation:  Nano Lett.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-15     Completed Date:  2008-09-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2305-9     Citation Subset:  IM    
Affiliation:
Department of Mathematical and Design Engineering, Gifu University, Japan. nittat@gifu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Computer Simulation
Diffusion
Kinesin / chemistry*
Male
Myosins / chemistry*
Rabbits
Time Factors
Chemical
Reg. No./Substance:
EC 3.6.1.-/Kinesin; EC 3.6.4.1/Myosins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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