Document Detail

Comparing exercise in Parkinson's disease--the Berlin LSVT®BIG study.
MedLine Citation:
PMID:  20669294     Owner:  NLM     Status:  MEDLINE    
Physiotherapy is widely used in Parkinson's disease (PD), but there are few controlled studies comparing active interventions. Recently, a technique named "LSVT®BIG" has been introduced. LSVT®BIG is derived from the Lee Silverman Voice Treatment and focuses on intensive exercising of high-amplitude movements. In the present comparative study, 60 patients with mild to moderate PD were randomly assigned to receive either one-to-one training (BIG), group training of Nordic Walking (WALK), or domestic nonsupervised exercises (HOME). Patients in training (BIG) and WALK received 16 hours of supervised training within 4 (BIG) or 8 (WALK) weeks. The primary efficacy measure was difference in change in Unified Parkinson's Disease Rating Scale (UPDRS) motor score from baseline to follow-up at 16 weeks between groups. UPDRS scores were obtained by blinded video rating. ANCOVA showed significant group differences for UPDRS-motor score at final assessment (P < 0.001). Mean improvement of UPDRS in BIG was -5.05 (SD 3.91) whereas there was a mild deterioration of 0.58 (SD 3.17) in WALK and of 1.68 (SD 5.95) in HOME. LSVT®BIG was also superior to WALK and HOME in timed-up-and-go and timed 10 m walking. There were no significant group differences for quality of life (PDQ39). These results provide evidence that LSVT®BIG is an effective technique to improve motor performance in patients with PD.
Georg Ebersbach; Almut Ebersbach; Daniela Edler; Olaf Kaufhold; Matthias Kusch; Andreas Kupsch; Jörg Wissel
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  25     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1902-8     Citation Subset:  IM    
Copyright Information:
© 2010 Movement Disorder Society.
Movement Disorders Clinic, Beelitz-Heilstätten, Germany.
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MeSH Terms
Analysis of Variance
Exercise Therapy*
Middle Aged
Parkinson Disease / rehabilitation*
Quality of Life
Treatment Outcome
Erratum In:
Mov Disord. 2010 Oct 30;25(14):2478

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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