Document Detail


Comparing the efficacy of urinary and recombinant hCG on oocyte/follicle ratio to trigger ovulation in women undergoing intracytoplasmic sperm injection cycles: a randomized controlled trial.
MedLine Citation:
PMID:  23274511     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare the number of oocytes per follicles in ovulation induction with 10,000 IU urinary hCG (uhCG) and two different doses of recombinant hCG (rhCG) in women undergoing intracytoplasmic sperm injection (ICSI) cycles.
METHODS: This study was a prospective, randomized controlled trial which was performed on 180 primary infertile women undergoing ICSI cycles. All eligible patients underwent a standard GnRH-a long protocol. When at least two follicles reached a diameter of 18 mm, all patients were randomized to receive 10,000 IU urinary hCG or 250 μg recombinant hCG or 500 μg recombinant hCG for ovulation induction. Primary outcome measure included the number of oocytes retrieved per aspirated follicles. Secondary outcome measures were the number of oocytes retrieved, the number of mature oocytes, the number and quality of generated embryos, fertilization rate, implantation rate, chemical and clinical pregnancy rates and OHSS occurrence rate.
RESULTS: The mean number of retrieved oocytes per follicles were 71.82 ± 15.09, 69.84 ± 17.44 and 77.16 ± 17.61 in 10,000 IU uhCG, 250 μg rhCG and 500 μg rhCG, respectively which was significantly higher with 500 μg rhCG than the lower dose(P = .04). Other cycles and clinical outcomes were comparable between groups.
CONCLUSION: Recombinant hCG shows equivalent efficacy to urinary hCG in terms of the number of oocytes per aspirated follicles in selected patients undergoing ICSI; however, 500 μg rhCG seems to be more advantageous than the lower dose in this indication. Larger randomized trials are needed to generalize this strategy.
Authors:
Tahereh Madani; Ladan Mohammadi Yeganeh; Zahra Ezabadi; Fatemeh Hasani; Mohammad Chehrazi
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-12-29
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  30     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-03     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01507376
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MeSH Terms
Descriptor/Qualifier:
Adult
Chorionic Gonadotropin / administration & dosage*
Embryo Transfer
Female
Fertilization in Vitro*
Humans
Infertility, Female / therapy*
Oocytes / drug effects,  growth & development*
Ovarian Follicle / drug effects,  growth & development
Ovarian Hyperstimulation Syndrome / drug therapy
Ovulation / drug effects
Pregnancy
Pregnancy Rate
Sperm Injections, Intracytoplasmic
Young Adult
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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