Document Detail


Comparing the efficacy of cisapride and ranitidine in oesophagitis: a double-blind, parallel group study in general practice.
MedLine Citation:
PMID:  8179973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with endoscopically confirmed oesophagitis (n = 49) were treated for 8 weeks with either cisapride (10 mg four times a day) or ranitidine (150 mg twice a day) in a double-blind study in general practice. Mean overall symptom scores fell from 10.8 to 4.5 in the cisapride group and from 9.9 to 4.4 in the ranitidine group over the course of the study. The proportion of patients reporting improvements in individual symptoms in the two treatment groups (cisapride and ranitidine respectively) were: heartburn, 66% and 55%; acid regurgitation, 53% and 47%; epigastric pain, 60% and 52%; satiety, 57% and 47%; bloating, 69% and 71%; belching, 65% and 72%; nausea, 62% and 85%; vomiting, 77% and 66%; poor appetite, 50% and 75%. Improvement in the endoscopic grade of oesophagitis was observed in 66% of patients receiving cisapride and 63% of those receiving ranitidine. It was concluded that cisapride is as effective as ranitidine in relieving the symptoms of oesophagitis and in healing oesophageal erosions.
Authors:
M Dakkak; B P Jones; M G Scott; P J Tooley; J R Bennett
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of clinical practice     Volume:  48     ISSN:  0007-0947     ISO Abbreviation:  Br J Clin Pract     Publication Date:    1994 Jan-Feb
Date Detail:
Created Date:  1994-06-14     Completed Date:  1994-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372546     Medline TA:  Br J Clin Pract     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  10-4     Citation Subset:  IM    
Affiliation:
Gastrointestinal Unit, Hull Royal Infirmary.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anti-Ulcer Agents / therapeutic use*
Cisapride
Double-Blind Method
Esophagitis / drug therapy*
Humans
Middle Aged
Piperidines / therapeutic use*
Ranitidine / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Piperidines; 66357-35-5/Ranitidine; 81098-60-4/Cisapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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