Document Detail


Comparing the effects of food restriction and overeating on brain reward systems.
MedLine Citation:
PMID:  23535488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both caloric restriction and overeating have been shown to affect neural processes associated with reinforcement. Both preclinical and some clinical studies have provided evidence that food restriction may increase reward sensitivity, and while there are mixed findings regarding the effects of overeating on reward sensitivity, there is strong evidence linking this behavior with changes in reward-related brain regions. Evidence of these changes comes in part from findings that show that such eating patterns are associated with increased drug use. The data discussed here regarding the differential effects of various eating patterns on reward systems may be particularly relevant to the aging population, as this population has been shown to exhibit altered reward sensitivity and decreased caloric consumption. Moreover, members of this population appear to be increasingly affected by the current obesity epidemic. Food, like alcohol or drugs, can stimulate its own consumption and produce similar neurochemical changes in the brain. Age-related loss of appetite, decreased eating, and caloric restriction are hypothesized to be associated with changes in the prevalence of substance misuse, abuse, and dependence seen in this cohort.
Authors:
Nicole M Avena; Susan Murray; Mark S Gold
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-03-25
Journal Detail:
Title:  Experimental gerontology     Volume:  48     ISSN:  1873-6815     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-02     Completed Date:  2014-03-11     Revised Date:  2014-05-11    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1062-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Caloric Restriction*
Feeding Behavior / physiology*
Food Deprivation / physiology
Hyperphagia / physiopathology*
Models, Animal
Reward*
Grant Support
ID/Acronym/Agency:
DA-03123/DA/NIDA NIH HHS; K01 DA031230/DA/NIDA NIH HHS
Comments/Corrections

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