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Comparing effects of clonazepam and zolpidem on sleep quality of patients on maintenance hemodialysis.
MedLine Citation:
PMID:  22057073     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction. Poor sleep quality is very common among maintenance hemodialysis patients and has negative impacts on patients' quality of life. Benzodiazepines have traditionally been used in this population; however, they may induce physical dependence and sleep apnea. Nonbenzodiazepine hypnotic medications with less side effects are introduced as alternatives. This study was designed to compare the effect of zolpidem and clonazepam on sleep quality of hemodialysis patients. Materials and Methods. In a randomized crossover study on 23 hemodialysis patients, sleep quality was assessed using the Pittsburgh Sleep Quality Index at baseline, at the initiation of a 1-week washout period after a 2-week treatment with zolpidem (1 mg) and clonazepam (5 mg to 10 mg), and after the second 2 weeks of treatment. Patients who suffer from any concurrent situations that may affect sleep quality or psychiatric disorders and those on medications affecting sleep quality were excluded. Results. The prevalence of poor sleep quality was 87.8% of the 88 hemodialysis patients who were initially approached. There was a significant negative correlation between iron deficiency and poor sleep quality. Both clonazepam and zolpidem significantly improved sleep quality; however, clonazepam was more effective in decreasing the Pittsburgh Sleep Quality Index scores (P = .03). Zolpidem was better tolerated in the hemodialysis patients. Conclusions. Clonazepam was more effective than zolpidem in the improvement of sleep quality of hemodialysis patients, while zolpidem was better tolerated in these patients.
Authors:
Simin Dashti-Khavidaki; Nastaran Chamani; Hossein Khalili; Azita Hajhossein Talasaz; Farokhlegha Ahmadi; Mahboob Lessan-Pezeshki; Padideh Ghaeli; Shirin Dalili; Abbas Alimadadi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of kidney diseases     Volume:  5     ISSN:  1735-8604     ISO Abbreviation:  Iran J Kidney Dis     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101316967     Medline TA:  Iran J Kidney Dis     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  404-9     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacy, Faculty of Pharmacy and Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran. dashtis@sina.tums.ac.ir.
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