Document Detail

Comparing bimatoprost and travoprost in black Americans.
MedLine Citation:
PMID:  17076978     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the intraocular pressure-lowering efficacy and safety of topical bimatoprost 0.03% with that of travoprost 0.004% for the treatment of black patients with open-angle glaucoma (OAG) and ocular hypertension (OHT). RESEARCH DESIGN AND METHODS: Multicenter, prospective, randomized, investigator-masked trial of 94 black patients previously diagnosed with OAG or OHT. All patients completed washout of ocular hypotensive medications before study participation. Patients were assigned to either once-daily bimatoprost 0.03% or once-daily travoprost 0.004% for 3 months. MAIN OUTCOME MEASURES: The primary outcome measures were mean intraocular pressure (IOP), mean change from baseline IOP, and percentage of patients who reached a target IOP reduction. Secondary measures included ophthalmologic examination and adverse events. RESULTS: Both bimatoprost and travoprost significantly lowered IOP at all study visits (p < 0.001). Bimatoprost provided mean IOP reductions from baseline that ranged from 6.8 mmHg to 7.8 mmHg (27% to 31%). Travoprost provided mean IOP reductions from baseline that ranged from 6.2 mmHg to 6.9 mmHg (25% to 28%). By month 3, 85% of participants in the bimatoprost group had a mean IOP reduction of at least 20%, compared with 68% of those in the travoprost group. Furthermore, 31.9% of those in the bimatoprost group had a mean IOP reduction of more than 40% at month 3 compared with 20.9% of those in the travoprost group. There were no significant differences in biomicroscopy, ophthalmoscopy, or visual acuity. Ocular redness was the most commonly reported adverse event in both treatment groups. No serious adverse events were reported. CONCLUSIONS: Bimatoprost and travoprost each effectively lowered IOP in this population of black patients. More patients achieved clinically relevant IOP reductions with bimatoprost.
Robert J Noecker; Melissa L Earl; Thomas K Mundorf; Steven M Silverstein; Michael P Phillips
Related Documents :
15575828 - Comparison of the tono-pen and goldmann tonometer for measuring intraocular pressure in...
21267208 - Screening for hypertension in family practice.
16644608 - Prospective comparative switch study from timolol 0.5% and latanoprost 0.005% to bimato...
1977708 - Cardiovascular effects of befunolol, betaxolol and timolol eye drops.
23970958 - Pathophysiology of vascular remodeling in hypertension.
16456438 - Elevated orbital pressure: another untoward effect of massive resuscitation after burn ...
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current medical research and opinion     Volume:  22     ISSN:  1473-4877     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-01     Completed Date:  2006-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  England    
Other Details:
Languages:  eng     Pagination:  2175-80     Citation Subset:  IM    
Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. noeckerrj@UPMC.EDU
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Topical
African Americans*
Amides / administration & dosage,  adverse effects,  therapeutic use*
Cloprostenol / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Glaucoma, Open-Angle / drug therapy*,  ethnology*,  pathology,  physiopathology
Intraocular Pressure / drug effects
Lipids / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Ocular Hypertension / drug therapy*,  ethnology*,  pathology,  physiopathology
Single-Blind Method
Treatment Outcome
Visual Acuity / drug effects
Reg. No./Substance:
0/Amides; 0/Lipids; 0/bimatoprost; 157283-68-6/travoprost; 40665-92-7/Cloprostenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Assessing glucose meter accuracy.
Next Document:  Carotid intima-media thickness as a surrogate marker for cardiovascular disease in intervention stud...