Document Detail


Comparing the Pharmacokinetics of Doxylamine/Pyridoxine Delayed-Release Combination in Nonpregnant Women of Reproductive Age and Women in the First Trimester of Pregnancy.
MedLine Citation:
PMID:  22549995     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described. The objective of this study was to compare the PK of doxylamine/pyridoxine delayed-released combination in pregnant versus nonpregnant women. The apparent clearances (CL) of doxylamine and pyridoxal 5'-phosphate (PLP; the active metabolite of vitamin B(6)) during the first-trimester pregnancy in women who participated in a Diclectin randomized trial were compared with those of healthy, adult, nonpregnant women who participated in a voluntary PK trial. Eighteen nonpregnant women were compared with 50 pregnant women who were treated with Diclectin. There was no difference in the apparent CL of doxylamine in women in their first trimester of pregnancy when compared with nonpregnant women on day 4 (median = 196.7 vs 249.5 mL/h/kg, respectively, P = .065), day 8 (median = 248.4 vs 249.5 mL/h/kg, respectively, P = .82), and day 15 (median = 200.9 vs 249.5 mL/h/kg, respectively, P = .55). No difference was found in the apparent CL of PLP on day 15 (median = 342.3 vs 314.7 mL/h/kg, respectively, P = .92). There was no pregnancy-induced effect in the apparent CL of either doxylamine or PLP in women during the first trimester of pregnancy despite the existence of morning sickness.
Authors:
Ilan Matok; Shannon Clark; Steve Caritis; Menachem Miodovnik; Jason Umans; Gary Hankins; Gideon Koren
Related Documents :
22368905 - Anthropometric measurements as a risk for hypertensive disorders in pregnancy: a hospit...
22618195 - Supernumerary blastocyst cryopreservation: a key prognostic indicator for patients opti...
22439055 - The value of the middle cerebral to umbilical artery doppler ratio in the prediction of...
22302905 - Predictors of successful outcomes after external cephalic version in singleton term bre...
15946165 - Neuroendocrine regulation of prolactin secretion during late pregnancy: easing the tran...
11724205 - Hemodynamic responses to obstructive respiratory events during sleep are augmented in w...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-1
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  -     ISSN:  1552-4604     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Combination of Exposure-Response and Case-Control Analyses in Regulatory Decision Making.
Next Document:  Steady-State Pharmacokinetics of Etravirine and Lopinavir/Ritonavir Melt Extrusion Formulation, Alon...