Document Detail

Comparative yield of blood culture for fungi and mycobacteria, liver biopsy, and bone marrow biopsy in the diagnosis of fever of undetermined origin in human immunodeficiency virus-infected patients.
MedLine Citation:
PMID:  2302009     Owner:  NLM     Status:  MEDLINE    
The diagnostic yield of mycobacterial blood cultures, bone marrow biopsy, and liver biopsy for determining the cause of unexplained fever was compared prospectively in eight men and four women with serologic evidence of human immunodeficiency virus infection and fever of undetermined origin. Mycobacterial infection was found in 8 of the 12 patients (Mycobacterium tuberculosis in 3 and Mycobacterium avium in 5). Mycobacteria were isolated from the blood of 6 of these 8 patients. The mean interval from blood culture inoculation to growth was 28 days. Acid-fast organisms or granulomas were seen in four bone marrow and six liver specimens. Liver biopsy revealed acid-fast bacilli in a higher percentage of cases (75%) than did bone marrow biopsy (25%). Mycobacterial blood culture is a relatively slow method that occasionally fails to diagnose mycobacterial infection. In febrile patients infected with human immunodeficiency virus, liver biopsy is the most rapid method of diagnosing mycobacterial infection.
V Prego; A E Glatt; V Roy; W Thelmo; H Dincsoy; J P Raufman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  150     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-15     Completed Date:  1990-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-6     Citation Subset:  AIM; IM; X    
Department of Medicine, State University of New York-Health Science Center, Brooklyn 11203.
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MeSH Terms
Bone Marrow / pathology*
Fever of Unknown Origin / etiology*,  microbiology
HIV Infections / complications*
Liver / pathology*
Middle Aged
Mycobacterium Infections / complications*,  diagnosis
Mycobacterium avium-intracellulare Infection / complications
Mycoses / complications,  diagnosis
Prospective Studies
Tuberculosis / complications
Comment In:
Arch Intern Med. 1990 Oct;150(10):2204   [PMID:  2222108 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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